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Target Report Card

Target Name and Classification

Target ID CHEMBL3271
Target Type SINGLE PROTEIN
Preferred Name Sodium-dependent vitamin C transporter 2
Synonyms KIAA0238 | NBTL1 | Na(+)/L-ascorbic acid transporter 2 | Nucleobase transporter-like 1 protein | SLC23A1 | SLC23A2 | SVCT2 | Sodium-dependent vitamin C transporter 2 | Solute carrier family 23 member 2 | YSPL2 | Yolk sac permease-like molecule 2 | hSVCT2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc23 family of ascorbic acid transporters

Target Components

Component Description Relationship Accession
Solute carrier family 23 member 2 SINGLE PROTEIN Q9UGH3

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000089057
Ensembl ENSG00000089057
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009925 (basal plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0016324 (apical plasma membrane)
GO Molecular Function GO:0005215 (transporter activity)
GO:0008520 (L-ascorbate:sodium symporter activity)
GO:0008523 (sodium-dependent multivitamin transmembrane transporter activity)
GO:0015205 (nucleobase transmembrane transporter activity)
GO:0015229 (L-ascorbic acid transporter activity)
GO:0015293 (symporter activity)
GO:0070890 (sodium-dependent L-ascorbate transmembrane transporter activity)
GO Biological Process GO:0006139 (nucleobase-containing compound metabolic process)
GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006814 (sodium ion transport)
GO:0006979 (response to oxidative stress)
GO:0015851 (nucleobase transport)
GO:0015882 (L-ascorbic acid transport)
GO:0015993 (molecular hydrogen transport)
GO:0019852 (L-ascorbic acid metabolic process)
GO:0035461 (vitamin transmembrane transport)
GO:0055085 (transmembrane transport)
GO:0070904 (transepithelial L-ascorbic acid transport)
GO:1905039 (carboxylic acid transmembrane transport)
Wikipedia SLC23A2

Target Cross References - Protein

canSAR Q9UGH3
Human Protein Atlas ENSG00000089057
IntAct Q9UGH3
Open Targets ENSG00000089057
PharmGKB PA35849
Reactome R-HSA-196836 (Vitamin C (ascorbate) metabolism.)
UniProt B4DJZ1 Q8WWR4 Q92512 Q96D54 Q9UGH3 Q9UNU1 Q9UP85

Target Cross References - Domain

InterPro IPR006042 (Xan_ur_permease.)
IPR006043 (Xant/urac/vitC.)
IPR029956 (SlC23A2.)
Pfam PF00860 (Xan_ur_permease)
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