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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3269
Target Type SINGLE PROTEIN
Preferred Name Galactoside 3(4)-L-fucosyltransferase
Synonyms Blood group Lewis alpha-4-fucosyltransferase | FT3B | FUT3 | FucT-III | Fucosyltransferase 3 | Fucosyltransferase III | Galactoside 3(4)-L-fucosyltransferase | LE | Lewis FT
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Galactoside 3(4)-L-fucosyltransferase SINGLE PROTEIN P21217

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000171124
Ensembl ENSG00000171124
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005794 (Golgi apparatus)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0032580 (Golgi cisterna membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0008417 (fucosyltransferase activity)
GO:0016740 (transferase activity)
GO:0016757 (transferase activity, transferring glycosyl groups)
GO:0017060 (3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity)
GO:0046920 (alpha-(1->3)-fucosyltransferase activity)
GO Biological Process GO:0006486 (protein glycosylation)
GO:0006672 (ceramide metabolic process)
GO:0009312 (oligosaccharide biosynthetic process)
GO:0009988 (cell-cell recognition)
GO:0036065 (fucosylation)
GO:0043413 (macromolecule glycosylation)
Wikipedia Fucosyltransferase_3

Target Cross References - Protein

canSAR P21217
CGD Blood group, Lewis
Human Protein Atlas ENSG00000171124
IntAct P21217
Open Targets ENSG00000171124
PharmGKB PA28430
Reactome R-HSA-975578 (Reactions specific to the complex N-glycan synthesis pathway.)
UniProt B5U7U9 B5U7V0 P21217 Q32NE7 Q99448 Q99449

Target Cross References - Domain

InterPro IPR001503 (Glyco_trans_10.)
IPR031481 (Glyco_tran_10_N.)
Pfam PF00852 (Glyco_transf_10)
PF17039 (Glyco_tran_10_N)
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