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Target Report Card

Target Name and Classification

Target ID CHEMBL3267
Target Type SINGLE PROTEIN
Preferred Name PI3-kinase p110-gamma subunit
Synonyms PI3-kinase subunit gamma | PI3K-gamma | PI3Kgamma | PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Phosphoinositide-3-kinase catalytic gamma polypeptide | PtdIns-3-kinase subunit gamma | PtdIns-3-kinase subunit p110-gamma | Serine/threonine protein kinase PIK3CG | p110gamma | p120-PI3K
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform SINGLE PROTEIN P48736

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3559703 PI3-kinase class I PROTEIN COMPLEX GROUP

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3039502 DUVELISIB PI3-kinase p110-gamma subunit inhibitor 3 PubMed
CHEMBL230011 TG100-115 PI3-kinase p110-gamma subunit inhibitor 2 PubMed
CHEMBL3545141 RP-6530 PI3-kinase p110-gamma subunit inhibitor 1 DOI Other
CHEMBL3545247 CAL-263 PI3-kinase p110-gamma subunit inhibitor 1 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000105851
Ensembl ENSG00000105851
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005942 (phosphatidylinositol 3-kinase complex)
GO:0005944 (phosphatidylinositol 3-kinase complex, class IB)
GO:0016020 (membrane)
GO:0042629 (mast cell granule)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016303 (1-phosphatidylinositol-3-kinase activity)
GO:0016740 (transferase activity)
GO:0035004 (phosphatidylinositol 3-kinase activity)
GO:0035005 (1-phosphatidylinositol-4-phosphate 3-kinase activity)
GO:0046875 (ephrin receptor binding)
GO:0046934 (phosphatidylinositol-4,5-bisphosphate 3-kinase activity)
GO Biological Process GO:0001525 (angiogenesis)
GO:0001816 (cytokine production)
GO:0001932 (regulation of protein phosphorylation)
GO:0002250 (adaptive immune response)
GO:0002376 (immune system process)
GO:0002407 (dendritic cell chemotaxis)
GO:0002675 (positive regulation of acute inflammatory response)
GO:0002679 (respiratory burst involved in defense response)
GO:0006468 (protein phosphorylation)
GO:0006661 (phosphatidylinositol biosynthetic process)
GO:0006897 (endocytosis)
GO:0006935 (chemotaxis)
GO:0006954 (inflammatory response)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0010818 (T cell chemotaxis)
GO:0010897 (negative regulation of triglyceride catabolic process)
GO:0014065 (phosphatidylinositol 3-kinase signaling)
GO:0016310 (phosphorylation)
GO:0030168 (platelet activation)
GO:0030593 (neutrophil chemotaxis)
GO:0032252 (secretory granule localization)
GO:0033628 (regulation of cell adhesion mediated by integrin)
GO:0035747 (natural killer cell chemotaxis)
GO:0036092 (phosphatidylinositol-3-phosphate biosynthetic process)
GO:0042098 (T cell proliferation)
GO:0042110 (T cell activation)
GO:0043085 (positive regulation of catalytic activity)
GO:0043303 (mast cell degranulation)
GO:0043406 (positive regulation of MAP kinase activity)
GO:0045087 (innate immune response)
GO:0046854 (phosphatidylinositol phosphorylation)
GO:0048015 (phosphatidylinositol-mediated signaling)
GO:0051897 (positive regulation of protein kinase B signaling)
GO:0055118 (negative regulation of cardiac muscle contraction)
GO:0070527 (platelet aggregation)
GO:0071320 (cellular response to cAMP)
GO:0072672 (neutrophil extravasation)
GO:0097284 (hepatocyte apoptotic process)
GO:1903169 (regulation of calcium ion transmembrane transport)
GO:2000270 (negative regulation of fibroblast apoptotic process)
Wikipedia PIK3CG

Target Cross References - Protein

canSAR P48736
Human Protein Atlas ENSG00000105851
IntAct P48736
Guide to Pharmacology 2156
Open Targets ENSG00000105851
PharmGKB PA33311
Pharos P48736 (Tchem)
Reactome R-HSA-114604 (GPVI-mediated activation cascade.)
R-HSA-1660499 (Synthesis of PIPs at the plasma membrane.)
R-HSA-392451 (G beta:gamma signalling through PI3Kgamma.)
UniProt A4D0Q6 P48736 Q8IV23 Q9BZC8

Target Cross References - Domain

InterPro IPR000008 (C2_dom.)
IPR000341 (PI3K_Ras-bd_dom.)
IPR000403 (PI3/4_kinase_cat_dom.)
IPR001263 (PInositide-3_kin_accessory_dom.)
IPR002420 (PI3K_C2_dom.)
IPR003113 (PI3K_adapt-bd_dom.)
IPR011009 (Kinase-like_dom.)
IPR015433 (PI_Kinase.)
IPR016024 (ARM-type_fold.)
IPR018936 (PI3/4_kinase_CS.)
IPR029071 (Ubiquitin-rel_dom.)
Pfam PF00454 (PI3_PI4_kinase)
PF00613 (PI3Ka)
PF00792 (PI3K_C2)
PF00794 (PI3K_rbd)

Target Cross References - Structure

PDBe 1E8Y 1E8Z 1HE8 2A4Z 2A5U 2CHW 2CHX 2CHZ 2V4L 3APC 3APD 3APF 3CSF 3CST 3DBS 3DPD 3ENE 3IBE 3L08 3L13 3L16 3L17 3L54 3LJ3 More...
CREDO 1E8Y 1E8Z 1HE8 2A4Z 2A5U 2CHW 2CHX 2CHZ 2V4L 3APC 3APD 3APF 3CSF 3CST 3DBS 3DPD 3ENE 3IBE 3L08 3L13 3L16 3L17 3L54 3LJ3 More...
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