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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3258
Target Type SINGLE PROTEIN
Preferred Name Leucyl-tRNA synthetase
Synonyms KIAA1352 | LARS | LeuRS | Leucine--tRNA ligase, cytoplasmic | Leucyl-tRNA synthetase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Leucine--tRNA ligase, cytoplasmic SINGLE PROTEIN Q9P2J5

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000133706
Ensembl ENSG00000133706
GO Cellular Component GO:0005829 (cytosol)
GO Molecular Function GO:0004823 (leucine-tRNA ligase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO Biological Process GO:0006429 (leucyl-tRNA aminoacylation)
Wikipedia Leucyl-tRNA_synthetase

Target Cross References - Protein

canSAR Q9P2J5
Human Protein Atlas ENSG00000133706
IntAct Q9P2J5
PharmGKB PA30297
Reactome REACT_71 (Gene Expression.)
UniProt A7E266 Q9NSE1 Q9P2J5

Target Cross References - Domain

InterPro IPR001412 (aa-tRNA-synth_I_CS.)
IPR002300 (Aminoacyl-tRNA-synth_Ia.)
IPR004493 (Leu-tRNA-synth_Ia_arc/euk.)
IPR009008 (Val/Leu/Ile-tRNA-synth_edit.)
IPR009080 (tRNAsynth_1a_anticodon-bd.)
IPR013155 (V/L/I-tRNA-synth_anticodon-bd.)
IPR014729 (Rossmann-like_a/b/a_fold.)
Pfam PF00133 (tRNA-synt_1)
PF08264 (Anticodon_1)

Target Cross References - Structure

PDBe 2WFD
CREDO 2WFD
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