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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3257
Target Type SINGLE PROTEIN
Preferred Name Aldehyde oxidase
Synonyms AO | AOX1 | Aldehyde oxidase | Aldehyde oxidase 1 | Azaheterocycle hydroxylase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Aldehyde oxidase SINGLE PROTEIN Q06278

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000138356
Ensembl ENSG00000138356
GO Cellular Component GO:0005737 (cytoplasm)
GO Molecular Function GO:0004031 (aldehyde oxidase activity)
GO:0004854 (xanthine dehydrogenase activity)
GO:0005506 (iron ion binding)
GO:0050660 (flavin adenine dinucleotide binding)
GO:0051287 (NAD binding)
GO:0051537 (2 iron, 2 sulfur cluster binding)
GO Biological Process GO:0006954 (inflammatory response)
GO:0072593 (reactive oxygen species metabolic process)
Wikipedia Aldehyde_oxidase_1

Target Cross References - Protein

canSAR Q06278
Human Protein Atlas ENSG00000138356
PharmGKB PA24842
UniProt O14765 Q06278 Q53RR8 Q53TV3 Q9BYF0 Q9UPG6

Target Cross References - Domain

InterPro IPR000674 (Ald_Oxase/Xan_DH_a/b.)
IPR001041 (Ferredoxin.)
IPR002346 (Mopterin_DH_FAD-bd.)
IPR002888 (2Fe-2S-bd.)
IPR005107 (CO_DH_flav_C.)
IPR006058 (2Fe2S_fd_BS.)
IPR008274 (AldOxase/xan_DH_Mopterin-bd.)
IPR012675 (Beta-grasp_ferredoxin-type.)
IPR014313 (Aldehyde_oxidase.)
IPR016166 (FAD-bd_2.)
IPR016167 (FAD-bd_2_sub1.)
IPR016169 (CO_DH_flavot_FAD-bd_sub2.)
IPR016208 (Ald_Oxase/xanthine_DH.)
IPR022407 (OxRdtase_Mopterin_BS.)
Pfam PF00111 (Fer2)
PF00941 (FAD_binding_5)
PF01315 (Ald_Xan_dh_C)
PF01799 (Fer2_2)
PF02738 (Ald_Xan_dh_C2)
PF03450 (CO_deh_flav_C)
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