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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3255
Target Type SINGLE PROTEIN
Preferred Name Activating transcription factor 1
Synonyms ATF1 | Activating transcription factor 1 | Cyclic AMP-dependent transcription factor ATF-1 | Protein TREB36 | cAMP-dependent transcription factor ATF-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor

Target Components

Component Description Relationship Accession
Cyclic AMP-dependent transcription factor ATF-1 SINGLE PROTEIN P18846

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000123268
Ensembl ENSG00000123268
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005667 (transcription factor complex)
GO:1990590 (ATF1-ATF4 transcription factor complex)
GO Molecular Function GO:0000977 (RNA polymerase II regulatory region sequence-specific DNA binding)
GO:0001228 (transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003705 (transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding)
GO:0005515 (protein binding)
GO:0032403 (protein complex binding)
GO:0043565 (sequence-specific DNA binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0010976 (positive regulation of neuron projection development)
GO:0014070 (response to organic cyclic compound)
GO:0032025 (response to cobalt ion)
GO:0043623 (cellular protein complex assembly)
GO:0045740 (positive regulation of DNA replication)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
Wikipedia ATF1

Target Cross References - Protein

canSAR P18846
Human Protein Atlas ENSG00000123268
IntAct P18846
Open Targets ENSG00000123268
PharmGKB PA25083
Reactome R-HSA-199920 (CREB phosphorylation.)
UniProt B4DRF9 P18846 P25168 Q9H4A8

Target Cross References - Domain

InterPro IPR001630 (Leuzip_CREB.)
IPR003102 (Coactivator_CBP_pKID.)
IPR004827 (bZIP.)
Pfam PF00170 (bZIP_1)
PF02173 (pKID)
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