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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3253
Preferred Name Serum albumin
Synonyms ALB | Serum albumin | UNQ696/PRO1341
Organism Homo sapiens
Species Group No
Protein Target Classification
  • secreted protein

Target Components

Component Description Relationship Accession
Serum albumin SINGLE PROTEIN P02768

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000163631
Ensembl ENSG00000163631
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005794 (Golgi apparatus)
GO:0031093 (platelet alpha granule lumen)
GO:0032991 (macromolecular complex)
GO:0043209 (myelin sheath)
GO:0070062 (extracellular exosome)
GO:0072562 (blood microparticle)
GO Molecular Function GO:0003677 (DNA binding)
GO:0005504 (fatty acid binding)
GO:0005507 (copper ion binding)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0008289 (lipid binding)
GO:0015643 (toxic substance binding)
GO:0016209 (antioxidant activity)
GO:0019825 (oxygen binding)
GO:0030170 (pyridoxal phosphate binding)
GO:0042802 (identical protein binding)
GO:0046872 (metal ion binding)
GO:0051087 (chaperone binding)
GO Biological Process GO:0001895 (retina homeostasis)
GO:0002576 (platelet degranulation)
GO:0006898 (receptor-mediated endocytosis)
GO:0009267 (cellular response to starvation)
GO:0015721 (bile acid and bile salt transport)
GO:0019836 (hemolysis by symbiont of host erythrocytes)
GO:0034375 (high-density lipoprotein particle remodeling)
GO:0043066 (negative regulation of apoptotic process)
GO:0043069 (negative regulation of programmed cell death)
GO:0043252 (sodium-independent organic anion transport)
GO:0043687 (post-translational protein modification)
GO:0044267 (cellular protein metabolic process)
GO:0051659 (maintenance of mitochondrion location)
GO:0098869 (cellular oxidant detoxification)
Wikipedia Serum_albumin

Target Cross References - Protein

canSAR P02768
CGD Dysalbuminemic hyperthyroxinemia; Analbuminemia
Human Protein Atlas ENSG00000163631
IntAct P02768
MICAD NBK23365 (Albumin)
Open Targets ENSG00000163631
PharmGKB PA24690
Reactome R-HSA-114608 (Platelet degranulation.)
R-HSA-159418 (Recycling of bile acids and salts.)
R-HSA-2168880 (Scavenging of heme from plasma.)
R-HSA-381426 (Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).)
R-HSA-5619058 (Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR).)
R-HSA-5619110 (Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR).)
R-HSA-879518 (Transport of organic anions.)
R-HSA-8957275 (Post-translational protein phosphorylation.)
R-HSA-8964058 (HDL remodeling.)
UniProt E7ESS9 O95574 P02768 P04277 Q13140 Q645G4 Q68DN5 Q6UXK4 Q86YG0 Q8IUK7 Q9P157 Q9P1I7 Q9UHS3 Q9UJZ0

Target Cross References - Domain

InterPro IPR000264 (ALB/AFP/VDB.)
IPR014760 (Serum_albumin_N.)
IPR020857 (Serum_albumin_CS.)
IPR020858 (Serum_albumin-like.)
IPR021177 (Serum_albumin/AFP/Afamin.)
Pfam PF00273 (Serum_albumin)

Target Cross References - Structure

PDBe 1AO6 1BJ5 1BKE 1BM0 1E78 1E7A 1E7B 1E7C 1E7E 1E7F 1E7G 1E7H 1E7I 1GNI 1GNJ 1H9Z 1HA2 1HK1 1HK2 1HK3 1HK4 1HK5 1N5U 1O9X More...
CREDO 1AO6 1BJ5 1BKE 1BM0 1E78 1E7A 1E7B 1E7C 1E7E 1E7F 1E7G 1E7H 1E7I 1GNI 1GNJ 1H9Z 1HA2 1HK1 1HK2 1HK3 1HK4 1HK5 1N5U 1O9X More...