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Target Report Card

Target Name and Classification

Target ID CHEMBL3251
Target Type SINGLE PROTEIN
Preferred Name Nuclear factor NF-kappa-B p105 subunit
Synonyms DNA-binding factor KBF1 | EBP-1 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | Nuclear factor NF-kappa-B p50 subunit | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other cytosolic protein
  • transcription factor

Target Components

Component Description Relationship Accession
Nuclear factor NF-kappa-B p105 subunit SINGLE PROTEIN P19838

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094258 Nuclear factor NF-kappa-B complex PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000109320
Ensembl ENSG00000109320
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO:0033256 (I-kappaB/NF-kappaB complex)
GO:0043005 (neuron projection)
GO:0043234 (protein complex)
GO Molecular Function GO:0000975 (regulatory region DNA binding)
GO:0000976 (transcription regulatory region sequence-specific DNA binding)
GO:0000977 (RNA polymerase II regulatory region sequence-specific DNA binding)
GO:0000980 (RNA polymerase II distal enhancer sequence-specific DNA binding)
GO:0001205 (transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding)
GO:0001227 (transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding)
GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0003690 (double-stranded DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0031072 (heat shock protein binding)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0042805 (actinin binding)
GO:0043565 (sequence-specific DNA binding)
GO:0044212 (transcription regulatory region DNA binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001818 (negative regulation of cytokine production)
GO:0002223 (stimulatory C-type lectin receptor signaling pathway)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006915 (apoptotic process)
GO:0006954 (inflammatory response)
GO:0006979 (response to oxidative stress)
GO:0007165 (signal transduction)
GO:0007249 (I-kappaB kinase/NF-kappaB signaling)
GO:0009617 (response to bacterium)
GO:0010628 (positive regulation of gene expression)
GO:0010744 (positive regulation of macrophage derived foam cell differentiation)
GO:0010884 (positive regulation of lipid storage)
GO:0010956 (negative regulation of calcidiol 1-monooxygenase activity)
GO:0010957 (negative regulation of vitamin D biosynthetic process)
GO:0014070 (response to organic cyclic compound)
GO:0031293 (membrane protein intracellular domain proteolysis)
GO:0032269 (negative regulation of cellular protein metabolic process)
GO:0032375 (negative regulation of cholesterol transport)
GO:0032481 (positive regulation of type I interferon production)
GO:0035994 (response to muscle stretch)
GO:0038061 (NIK/NF-kappaB signaling)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0043066 (negative regulation of apoptotic process)
GO:0045083 (negative regulation of interleukin-12 biosynthetic process)
GO:0045087 (innate immune response)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046688 (response to copper ion)
GO:0050728 (negative regulation of inflammatory response)
GO:0050852 (T cell receptor signaling pathway)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051403 (stress-activated MAPK cascade)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0071260 (cellular response to mechanical stimulus)
GO:0071316 (cellular response to nicotine)
GO:0071322 (cellular response to carbohydrate stimulus)
GO:0071347 (cellular response to interleukin-1)
GO:0071354 (cellular response to interleukin-6)
GO:0071356 (cellular response to tumor necrosis factor)
GO:0071359 (cellular response to dsRNA)
GO:0071375 (cellular response to peptide hormone stimulus)
GO:0071407 (cellular response to organic cyclic compound)
GO:0090263 (positive regulation of canonical Wnt signaling pathway)
GO:1900127 (positive regulation of hyaluronan biosynthetic process)
GO:1901653 (cellular response to peptide)
GO:1904630 (cellular response to diterpene)
GO:1904632 (cellular response to glucoside)
GO:1990416 (cellular response to brain-derived neurotrophic factor stimulus)
GO:2000630 (positive regulation of miRNA metabolic process)
Wikipedia NFKB1

Target Cross References - Protein

canSAR P19838
Human Protein Atlas ENSG00000109320
IntAct P19838
Open Targets ENSG00000109320
PharmGKB PA248
Reactome R-HSA-1169091 (Activation of NF-kappaB in B cells.)
R-HSA-1810476 (RIP-mediated NFkB activation via ZBP1.)
R-HSA-193692 (Regulated proteolysis of p75NTR.)
R-HSA-202424 (Downstream TCR signaling.)
R-HSA-209560 (NF-kB is activated and signals survival.)
R-HSA-2559582 (Senescence-Associated Secretory Phenotype (SASP).)
R-HSA-2871837 (FCERI mediated NF-kB activation.)
R-HSA-3134963 (DEx/H-box helicases activate type I IFN and inflammatory cytokines production.)
R-HSA-3214841 (PKMTs methylate histone lysines.)
R-HSA-381340 (Transcriptional regulation of white adipocyte differentiation.)
R-HSA-445989 (TAK1 activates NFkB by phosphorylation and activation of IKKs complex.)
R-HSA-448706 (Interleukin-1 processing.)
R-HSA-5603027 (IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR).)
R-HSA-5603029 (IkBA variant leads to EDA-ID.)
R-HSA-5607764 (CLEC7A (Dectin-1) signaling.)
R-HSA-5621575 (CD209 (DC-SIGN) signaling.)
R-HSA-5660668 (CLEC7A/inflammasome pathway.)
R-HSA-5684264 (MAP3K8 (TPL2)-dependent MAPK1/3 activation.)
R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-933542 (TRAF6 mediated NF-kB activation.)
UniProt A8K5Y5 B3KVE8 P19838 Q68D84 Q86V43 Q8N4X7 Q9NZC0

Target Cross References - Domain

InterPro IPR000451 (NFkB/Dor.)
IPR000488 (Death_domain.)
IPR002110 (Ankyrin_rpt.)
IPR002909 (IPT.)
IPR008967 (p53-like_TF_DNA-bd.)
IPR011029 (DEATH-like_dom.)
IPR011539 (RHD_DNA_bind_dom.)
IPR013783 (Ig-like_fold.)
IPR014756 (Ig_E-set.)
IPR020683 (Ankyrin_rpt-contain_dom.)
IPR030492 (RHD_CS.)
IPR030503 (NF-kB_p105.)
IPR032397 (RHD_dimer.)
IPR033926 (IPT_NFkappaB.)
Pfam PF00531 (Death)
PF00554 (RHD_DNA_bind)
PF12796 (Ank_2)
PF16179 (RHD_dimer)

Target Cross References - Structure

PDBe 1NFI 1SVC 2O61 3GUT
CREDO 1NFI 1SVC 2O61 3GUT
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