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Target Report Card

Target Name and Classification

Target ID CHEMBL325
Target Type SINGLE PROTEIN
Preferred Name Histone deacetylase 1
Synonyms HD1 | HDAC1 | Histone deacetylase 1 | RPD3L1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > eraser > histone deacetylase > hdac class i

Target Components

Component Description Relationship Accession
Histone deacetylase 1 SINGLE PROTEIN Q13547

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3430896 Histone deacetylase 1/2/3/6 PROTEIN FAMILY
CHEMBL3038483 Histone deacetylase 1/3/5/8 PROTEIN FAMILY
CHEMBL3430897 Histone deacetylase 1/2/3 PROTEIN FAMILY
CHEMBL2093865 Histone deacetylase PROTEIN FAMILY
CHEMBL3885589 Histone deacetylase 1/8 PROTEIN FAMILY
CHEMBL2111429 Histone deacetylase (HDAC1 and HDAC2) PROTEIN FAMILY
CHEMBL3885590 Histone deacetylase 1/Nuclear receptor corepressor 2 PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL98 VORINOSTAT Histone deacetylase 1 inhibitor 4 DailyMed
CHEMBL272980 MOCETINOSTAT Histone deacetylase 1 inhibitor 2 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000116478
Ensembl ENSG00000116478
GO Cellular Component GO:0000118 (histone deacetylase complex)
GO:0000785 (chromatin)
GO:0000790 (nuclear chromatin)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0016580 (Sin3 complex)
GO:0016581 (NuRD complex)
GO:0032991 (macromolecular complex)
GO Molecular Function GO:0000976 (transcription regulatory region sequence-specific DNA binding)
GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0000980 (RNA polymerase II distal enhancer sequence-specific DNA binding)
GO:0001046 (core promoter sequence-specific DNA binding)
GO:0001047 (core promoter binding)
GO:0001085 (RNA polymerase II transcription factor binding)
GO:0001103 (RNA polymerase II repressing transcription factor binding)
GO:0001106 (RNA polymerase II transcription corepressor activity)
GO:0002039 (p53 binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0004407 (histone deacetylase activity)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0016787 (hydrolase activity)
GO:0019213 (deacetylase activity)
GO:0019899 (enzyme binding)
GO:0031492 (nucleosomal DNA binding)
GO:0032041 (NAD-dependent histone deacetylase activity (H3-K14 specific))
GO:0033558 (protein deacetylase activity)
GO:0033613 (activating transcription factor binding)
GO:0042826 (histone deacetylase binding)
GO:0044212 (transcription regulatory region DNA binding)
GO:0047485 (protein N-terminus binding)
GO:0051059 (NF-kappaB binding)
GO:0070491 (repressing transcription factor binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0006325 (chromatin organization)
GO:0006338 (chromatin remodeling)
GO:0006346 (methylation-dependent chromatin silencing)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006476 (protein deacetylation)
GO:0007596 (blood coagulation)
GO:0008284 (positive regulation of cell proliferation)
GO:0009913 (epidermal cell differentiation)
GO:0010629 (negative regulation of gene expression)
GO:0010832 (negative regulation of myotube differentiation)
GO:0010870 (positive regulation of receptor biosynthetic process)
GO:0016032 (viral process)
GO:0016575 (histone deacetylation)
GO:0032922 (circadian regulation of gene expression)
GO:0042475 (odontogenesis of dentin-containing tooth)
GO:0042733 (embryonic digit morphogenesis)
GO:0043044 (ATP-dependent chromatin remodeling)
GO:0043066 (negative regulation of apoptotic process)
GO:0043922 (negative regulation by host of viral transcription)
GO:0045652 (regulation of megakaryocyte differentiation)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048511 (rhythmic process)
GO:0060766 (negative regulation of androgen receptor signaling pathway)
GO:0060789 (hair follicle placode formation)
GO:0061029 (eyelid development in camera-type eye)
GO:0061198 (fungiform papilla formation)
GO:0070932 (histone H3 deacetylation)
GO:0070933 (histone H4 deacetylation)
GO:0090090 (negative regulation of canonical Wnt signaling pathway)
GO:1901796 (regulation of signal transduction by p53 class mediator)
GO:1904837 (beta-catenin-TCF complex assembly)
Wikipedia HDAC1

Target Cross References - Protein

canSAR Q13547
Human Protein Atlas ENSG00000116478
IntAct Q13547
Guide to Pharmacology 2658
Open Targets ENSG00000116478
PharmGKB PA29226
Reactome R-HSA-1362277 (Transcription of E2F targets under negative control by DREAM complex.)
R-HSA-1362300 (Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1.)
R-HSA-1538133 (G0 and Early G1.)
R-HSA-193670 (p75NTR negatively regulates cell cycle via SC1.)
R-HSA-201722 (Formation of the beta-catenin:TCF transactivating complex.)
R-HSA-2122947 (NOTCH1 Intracellular Domain Regulates Transcription.)
R-HSA-2173795 (Downregulation of SMAD2/3:SMAD4 transcriptional activity.)
R-HSA-2173796 (SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.)
R-HSA-2644606 (Constitutive Signaling by NOTCH1 PEST Domain Mutants.)
R-HSA-2894862 (Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.)
R-HSA-3214815 (HDACs deacetylate histones.)
R-HSA-3769402 (Deactivation of the beta-catenin transactivating complex.)
R-HSA-427389 (ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression.)
R-HSA-427413 (NoRC negatively regulates rRNA expression.)
R-HSA-4551638 (SUMOylation of chromatin organization proteins.)
R-HSA-4641265 (Repression of WNT target genes.)
R-HSA-539107 (Activation of E2F1 target genes at G1/S.)
R-HSA-6804758 (Regulation of TP53 Activity through Acetylation.)
R-HSA-73762 (RNA Polymerase I Transcription Initiation.)
R-HSA-8936459 (RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function.)
R-HSA-8943724 (Regulation of PTEN gene transcription.)
R-HSA-983231 (Factors involved in megakaryocyte development and platelet production.)
UniProt Q13547 Q92534

Target Cross References - Domain

InterPro IPR000286 (His_deacetylse.)
IPR003084 (His_deacetylse_1.)
IPR023696 (Ureohydrolase_dom_sf.)
IPR023801 (His_deacetylse_dom.)
IPR037138 (His_deacetylse_dom_sf.)
Pfam PF00850 (Hist_deacetyl)

Target Cross References - Structure

PDBe 4BKX 5ICN
CREDO 4BKX 5ICN
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