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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL325
Target Type SINGLE PROTEIN
Preferred Name Histone deacetylase 1
Synonyms HD1 | HDAC1 | Histone deacetylase 1 | RPD3L1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > eraser > histone deacetylase > hdac class i

Target Components

Component Description Relationship Accession
Histone deacetylase 1 SINGLE PROTEIN Q13547

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038483 Histone deacetylase 1/3/5/8 PROTEIN FAMILY
CHEMBL2093865 Histone deacetylase PROTEIN FAMILY
CHEMBL2111429 Histone deacetylase (HDAC1 and HDAC2) PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL98 VORINOSTAT Histone deacetylase 1 inhibitor 4 DailyMed
CHEMBL272980 MOCETINOSTAT Histone deacetylase 1 inhibitor 2 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000116478
Ensembl ENSG00000116478
GO Cellular Component GO:0000118 (histone deacetylase complex)
GO:0000785 (chromatin)
GO:0000790 (nuclear chromatin)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0016580 (Sin3 complex)
GO:0016581 (NuRD complex)
GO:0043234 (protein complex)
GO Molecular Function GO:0000976 (transcription regulatory region sequence-specific DNA binding)
GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0000980 (RNA polymerase II distal enhancer sequence-specific DNA binding)
GO:0001047 (core promoter binding)
GO:0001085 (RNA polymerase II transcription factor binding)
GO:0001103 (RNA polymerase II repressing transcription factor binding)
GO:0001106 (RNA polymerase II transcription corepressor activity)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0004407 (histone deacetylase activity)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0016787 (hydrolase activity)
GO:0019213 (deacetylase activity)
GO:0019899 (enzyme binding)
GO:0031492 (nucleosomal DNA binding)
GO:0032041 (NAD-dependent histone deacetylase activity (H3-K14 specific))
GO:0033558 (protein deacetylase activity)
GO:0033613 (activating transcription factor binding)
GO:0042826 (histone deacetylase binding)
GO:0044212 (transcription regulatory region DNA binding)
GO:0047485 (protein N-terminus binding)
GO:0051059 (NF-kappaB binding)
GO:0070491 (repressing transcription factor binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0006338 (chromatin remodeling)
GO:0006346 (methylation-dependent chromatin silencing)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006476 (protein deacetylation)
GO:0007596 (blood coagulation)
GO:0008284 (positive regulation of cell proliferation)
GO:0009913 (epidermal cell differentiation)
GO:0010629 (negative regulation of gene expression)
GO:0010832 (negative regulation of myotube differentiation)
GO:0010870 (positive regulation of receptor biosynthetic process)
GO:0016032 (viral process)
GO:0016568 (chromatin modification)
GO:0016575 (histone deacetylation)
GO:0032922 (circadian regulation of gene expression)
GO:0042475 (odontogenesis of dentin-containing tooth)
GO:0042733 (embryonic digit morphogenesis)
GO:0043044 (ATP-dependent chromatin remodeling)
GO:0043066 (negative regulation of apoptotic process)
GO:0043922 (negative regulation by host of viral transcription)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048511 (rhythmic process)
GO:0060766 (negative regulation of androgen receptor signaling pathway)
GO:0060789 (hair follicle placode formation)
GO:0061029 (eyelid development in camera-type eye)
GO:0061198 (fungiform papilla formation)
GO:0070932 (histone H3 deacetylation)
GO:0070933 (histone H4 deacetylation)
GO:0090090 (negative regulation of canonical Wnt signaling pathway)
GO:1901796 (regulation of signal transduction by p53 class mediator)
GO:1904837 (beta-catenin-TCF complex assembly)
Wikipedia HDAC1

Target Cross References - Protein

canSAR Q13547
Human Protein Atlas ENSG00000116478
IntAct Q13547
Guide to Pharmacology 2658
Open Targets ENSG00000116478
PharmGKB PA29226
Reactome R-HSA-1538133 (G0 and Early G1.)
R-HSA-193670 (p75NTR negatively regulates cell cycle via SC1.)
R-HSA-201722 (Formation of the beta-catenin:TCF transactivating complex.)
R-HSA-2122947 (NOTCH1 Intracellular Domain Regulates Transcription.)
R-HSA-2173795 (Downregulation of SMAD2/3:SMAD4 transcriptional activity.)
R-HSA-2173796 (SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.)
R-HSA-2644606 (Constitutive Signaling by NOTCH1 PEST Domain Mutants.)
R-HSA-2894862 (Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.)
R-HSA-3214815 (HDACs deacetylate histones.)
R-HSA-3769402 (Deactivation of the beta-catenin transactivating complex.)
R-HSA-427389 (ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression.)
R-HSA-427413 (NoRC negatively regulates rRNA expression.)
R-HSA-4641265 (Repression of WNT target genes.)
R-HSA-6804758 (Regulation of TP53 Activity through Acetylation.)
R-HSA-73762 (RNA Polymerase I Transcription Initiation.)
R-HSA-983231 (Factors involved in megakaryocyte development and platelet production.)
UniProt Q13547 Q92534

Target Cross References - Domain

InterPro IPR000286 (His_deacetylse.)
IPR003084 (His_deacetylse_1.)
IPR023801 (His_deacetylse_dom.)
Pfam PF00850 (Hist_deacetyl)

Target Cross References - Structure

PDBe 4BKX 5ICN
CREDO 4BKX 5ICN
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