ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL3243
Target Type SINGLE PROTEIN
Preferred Name Leukocyte common antigen
Synonyms CD45 | CD_antigen=CD45 | L-CA | Leukocyte common antigen | PTPRC | Receptor-type tyrosine-protein phosphatase C | T200
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Receptor-type tyrosine-protein phosphatase C SINGLE PROTEIN P08575

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000081237 ENSG00000262418
Ensembl ENSG00000081237 ENSG00000262418
GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005925 (focal adhesion)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0045121 (membrane raft)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004721 (phosphoprotein phosphatase activity)
GO:0004725 (protein tyrosine phosphatase activity)
GO:0005001 (transmembrane receptor protein tyrosine phosphatase activity)
GO:0005515 (protein binding)
GO:0016787 (hydrolase activity)
GO:0016791 (phosphatase activity)
GO:0019901 (protein kinase binding)
GO Biological Process GO:0001915 (negative regulation of T cell mediated cytotoxicity)
GO:0001960 (negative regulation of cytokine-mediated signaling pathway)
GO:0002244 (hematopoietic progenitor cell differentiation)
GO:0002378 (immunoglobulin biosynthetic process)
GO:0006469 (negative regulation of protein kinase activity)
GO:0006470 (protein dephosphorylation)
GO:0006933 (negative regulation of cell adhesion involved in substrate-bound cell migration)
GO:0007166 (cell surface receptor signaling pathway)
GO:0016311 (dephosphorylation)
GO:0030217 (T cell differentiation)
GO:0030890 (positive regulation of B cell proliferation)
GO:0035335 (peptidyl-tyrosine dephosphorylation)
GO:0042100 (B cell proliferation)
GO:0042102 (positive regulation of T cell proliferation)
GO:0044770 (cell cycle phase transition)
GO:0045860 (positive regulation of protein kinase activity)
GO:0048539 (bone marrow development)
GO:0048864 (stem cell development)
GO:0050852 (T cell receptor signaling pathway)
GO:0050853 (B cell receptor signaling pathway)
GO:0050857 (positive regulation of antigen receptor-mediated signaling pathway)
GO:0051209 (release of sequestered calcium ion into cytosol)
GO:0051607 (defense response to virus)
GO:0051726 (regulation of cell cycle)
GO:2000473 (positive regulation of hematopoietic stem cell migration)
GO:2000648 (positive regulation of stem cell proliferation)
Wikipedia PTPRC

Target Cross References - Protein

canSAR P08575
CGD Severe combined immunodeficiency, autosomal recessive, T-cell negative, B-cell positive, NK cell positive
Human Protein Atlas ENSG00000081237 ENSG00000262418
IntAct P08575
Open Targets ENSG00000081237 ENSG00000262418
PharmGKB PA34011
Reactome R-HSA-202427 (Phosphorylation of CD3 and TCR zeta chains.)
R-HSA-416700 (Other semaphorin interactions.)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt A8K7W6 P08575 Q16614 Q9H0Y6

Target Cross References - Domain

InterPro IPR000242 (PTPase_domain.)
IPR000387 (TYR_PHOSPHATASE_dom.)
IPR003595 (Tyr_Pase_cat.)
IPR003961 (FN3_dom.)
IPR013783 (Ig-like_fold.)
IPR016130 (Tyr_Pase_AS.)
IPR016335 (Ptprc.)
IPR024739 (PTP_recept_N.)
IPR029021 (Prot-tyrosine_phosphatase-like.)
Pfam PF00041 (fn3)
PF00102 (Y_phosphatase)
PF12453 (PTP_N)
PF12567 (CD45)

Target Cross References - Structure

PDBe 1YGR 1YGU 5FMV 5FN6 5FN7
CREDO 1YGR 1YGU 5FMV 5FN6 5FN7
spacer
spacer