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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3242
Target Type SINGLE PROTEIN
Preferred Name Carbonic anhydrase XII
Synonyms CA-XII | CA12 | Carbonate dehydratase XII | Carbonic anhydrase 12 | Carbonic anhydrase XII | Tumor antigen HOM-RCC-3.1.3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > lyase

Target Components

Component Description Relationship Accession
Carbonic anhydrase 12 SINGLE PROTEIN O43570

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095180 Carbonic anhydrase PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL17 DICHLORPHENAMIDE Carbonic anhydrase XII inhibitor 4 PubMed
CHEMBL20 ACETAZOLAMIDE Carbonic anhydrase XII inhibitor 4 PubMed
CHEMBL1200814 ACETAZOLAMIDE SODIUM Carbonic anhydrase XII inhibitor 4 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000074410
Ensembl ENSG00000074410
GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004089 (carbonate dehydratase activity)
GO:0008270 (zinc ion binding)
GO:0016829 (lyase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006730 (one-carbon metabolic process)
GO:0015701 (bicarbonate transport)
GO:0055064 (chloride ion homeostasis)
Wikipedia CA12

Target Cross References - Protein

canSAR O43570
CGD Hyperchlorhidrosis, isolated
Human Protein Atlas ENSG00000074410
IntAct O43570
Guide to Pharmacology 2747
Open Targets ENSG00000074410
PharmGKB PA25987
Reactome R-HSA-1475029 (Reversible hydration of carbon dioxide.)
UniProt B2RE24 O43570 Q53YE5 Q9BWG2

Target Cross References - Domain

InterPro IPR001148 (Carbonic_anhydrase_a.)
IPR018338 (Carbonic_anhydrase_a-class_CS.)
IPR018430 (Carbonic_anhydrase_CA12.)
IPR023561 (Carbonic_anhydrase_a-class.)
Pfam PF00194 (Carb_anhydrase)

Target Cross References - Structure

PDBe 1JCZ 1JD0 4HT2 4KP5 4KP8 4Q0L 4QJ0 4QJO 4QJW 4WW8
CREDO 1JCZ 1JD0 4HT2 4KP5 4KP8 4Q0L 4QJ0 4QJO 4QJW 4WW8
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