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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3240
Target Type SINGLE PROTEIN
Preferred Name Insulin-like growth factor II receptor
Synonyms 300 kDa mannose 6-phosphate receptor | CD_antigen=CD222 | CI Man-6-P receptor | CI-MPR | Cation-independent mannose-6-phosphate receptor | IGF-II receptor | IGF2R | Insulin-like growth factor 2 receptor | Insulin-like growth factor II receptor | M6P/IGF2 receptor | M6P/IGF2R | M6PR | MPR 300 | MPRI
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Cation-independent mannose-6-phosphate receptor SINGLE PROTEIN P11717

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000197081
Ensembl ENSG00000197081
GO Cellular Component GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005641 (nuclear envelope lumen)
GO:0005737 (cytoplasm)
GO:0005764 (lysosome)
GO:0005765 (lysosomal membrane)
GO:0005768 (endosome)
GO:0005769 (early endosome)
GO:0005770 (late endosome)
GO:0005802 (trans-Golgi network)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005925 (focal adhesion)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030118 (clathrin coat)
GO:0030133 (transport vesicle)
GO:0030139 (endocytic vesicle)
GO:0030140 (trans-Golgi network transport vesicle)
GO:0032588 (trans-Golgi network membrane)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0001948 (glycoprotein binding)
GO:0001965 (G-protein alpha-subunit binding)
GO:0001972 (retinoic acid binding)
GO:0004872 (receptor activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0005010 (insulin-like growth factor-activated receptor activity)
GO:0005215 (transporter activity)
GO:0005515 (protein binding)
GO:0005520 (insulin-like growth factor binding)
GO:0005537 (mannose binding)
GO:0019899 (enzyme binding)
GO:0031995 (insulin-like growth factor II binding)
GO:0042802 (identical protein binding)
GO:0051219 (phosphoprotein binding)
GO Biological Process GO:0001889 (liver development)
GO:0006810 (transport)
GO:0006898 (receptor-mediated endocytosis)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007283 (spermatogenesis)
GO:0009791 (post-embryonic development)
GO:0031100 (organ regeneration)
GO:0032526 (response to retinoic acid)
GO:0042981 (regulation of apoptotic process)
GO:0043065 (positive regulation of apoptotic process)
GO:0048009 (insulin-like growth factor receptor signaling pathway)
Wikipedia Insulin-like_growth_factor_2_receptor

Target Cross References - Protein

Human Protein Atlas ENSG00000197081
IntAct P11717
Open Targets ENSG00000197081
PharmGKB PA29701
Reactome R-HSA-432722 (Golgi Associated Vesicle Biogenesis.)
R-HSA-6811440 (Retrograde transport at the Trans-Golgi-Network.)
UniProt P11717 Q7Z7G9 Q96PT5

Target Cross References - Domain

InterPro IPR000479 (CIMR.)
IPR000562 (FN_type2_col-bd.)
IPR009011 (Man6P_isomerase_rcpt-bd_dom.)
IPR013806 (Kringle-like.)
Pfam PF00040 (fn2)
PF00878 (CIMR)

Target Cross References - Structure

PDBe 1E6F 1GP0 1GP3 1GQB 1JPL 1JWG 1LF8 2V5N 2V5O 2V5P
CREDO 1E6F 1GP0 1GP3 1GQB 1JPL 1JWG 1LF8 2V5N 2V5O 2V5P
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