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Target Report Card

Target Name and Classification

Target ID CHEMBL3240
Preferred Name Insulin-like growth factor II receptor
Synonyms 300 kDa mannose 6-phosphate receptor | CD_antigen=CD222 | CI Man-6-P receptor | CI-MPR | Cation-independent mannose-6-phosphate receptor | IGF-II receptor | IGF2R | Insulin-like growth factor 2 receptor | Insulin-like growth factor II receptor | M6P/IGF2 receptor | M6P/IGF2R | M6PR | MPR 300 | MPRI
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Cation-independent mannose-6-phosphate receptor SINGLE PROTEIN P11717

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000197081
Ensembl ENSG00000197081
GO Cellular Component GO:0005765 (lysosomal membrane)
GO:0005768 (endosome)
GO:0005887 (integral to plasma membrane)
GO:0009986 (cell surface)
GO:0030139 (endocytic vesicle)
GO:0030140 (trans-Golgi network transport vesicle)
GO Molecular Function GO:0001948 (glycoprotein binding)
GO:0005010 (insulin-like growth factor receptor activity)
GO:0005215 (transporter activity)
GO:0051219 (phosphoprotein binding)
GO Biological Process GO:0006898 (receptor-mediated endocytosis)
Wikipedia Insulin-like_growth_factor_2_receptor

Target Cross References - Protein

Human Protein Atlas ENSG00000197081
IntAct P11717
PharmGKB PA29701
Reactome REACT_11123 (Membrane Trafficking.)
UniProt P11717 Q7Z7G9 Q96PT5

Target Cross References - Domain

InterPro IPR000479 (CIMR.)
IPR000562 (FN_type2_col-bd.)
IPR009011 (Man6P_isomerase_rcpt-bd.)
IPR013806 (Kringle-like.)
Pfam PF00040 (fn2)
PF00878 (CIMR)

Target Cross References - Structure

PDBe 1E6F 1GP0 1GP3 1GQB 1JWG 1LF8 2V5N 2V5O 2V5P
CREDO 1E6F 1GP0 1GP3 1GQB 1JWG 1LF8 2V5N 2V5O 2V5P