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Target Report Card

Target Name and Classification

Target ID CHEMBL3231
Target Type SINGLE PROTEIN
Preferred Name Rho-associated protein kinase 1
Synonyms ROCK-I | ROCK1 | Renal carcinoma antigen NY-REN-35 | Rho-associated protein kinase 1 | Rho-associated, coiled-coil-containing protein kinase 1 | Rho-associated, coiled-coil-containing protein kinase I | p160 ROCK-1 | p160ROCK
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase dmpk family > agc protein kinase rock subfamily

Target Components

Component Description Relationship Accession
Rho-associated protein kinase 1 SINGLE PROTEIN Q13464

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111459 Rho-associated protein kinase PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000067900
Ensembl ENSG00000067900
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0001726 (ruffle)
GO:0005737 (cytoplasm)
GO:0005794 (Golgi apparatus)
GO:0005814 (centriole)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0030027 (lamellipodium)
GO:0032059 (bleb)
GO:0042995 (cell projection)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0017048 (Rho GTPase binding)
GO:0017049 (GTP-Rho binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0003383 (apical constriction)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0006921 (cellular component disassembly involved in execution phase of apoptosis)
GO:0006939 (smooth muscle contraction)
GO:0007159 (leukocyte cell-cell adhesion)
GO:0007165 (signal transduction)
GO:0007249 (I-kappaB kinase/NF-kappaB signaling)
GO:0007266 (Rho protein signal transduction)
GO:0016310 (phosphorylation)
GO:0016525 (negative regulation of angiogenesis)
GO:0022614 (membrane to membrane docking)
GO:0030036 (actin cytoskeleton organization)
GO:0030155 (regulation of cell adhesion)
GO:0030866 (cortical actin cytoskeleton organization)
GO:0032060 (bleb assembly)
GO:0032091 (negative regulation of protein binding)
GO:0032956 (regulation of actin cytoskeleton organization)
GO:0032970 (regulation of actin filament-based process)
GO:0035509 (negative regulation of myosin-light-chain-phosphatase activity)
GO:0035556 (intracellular signal transduction)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0045616 (regulation of keratinocyte differentiation)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0048013 (ephrin receptor signaling pathway)
GO:0050900 (leukocyte migration)
GO:0050901 (leukocyte tethering or rolling)
GO:0051451 (myoblast migration)
GO:0051492 (regulation of stress fiber assembly)
GO:0051493 (regulation of cytoskeleton organization)
GO:0051893 (regulation of focal adhesion assembly)
GO:0051894 (positive regulation of focal adhesion assembly)
GO:0090002 (establishment of protein localization to plasma membrane)
GO:1903140 (regulation of establishment of endothelial barrier)
GO:1903347 (negative regulation of bicellular tight junction assembly)
GO:2000114 (regulation of establishment of cell polarity)
GO:2000145 (regulation of cell motility)
Wikipedia ROCK1

Target Cross References - Protein

canSAR Q13464
Human Protein Atlas ENSG00000067900
IntAct Q13464
Guide to Pharmacology 1503
Open Targets ENSG00000067900
PharmGKB PA34623
Pharos Q13464 (Tclin)
Reactome R-HSA-111465 (Apoptotic cleavage of cellular proteins.)
R-HSA-3928662 (EPHB-mediated forward signaling.)
R-HSA-3928663 (EPHA-mediated growth cone collapse.)
R-HSA-416482 (G alpha (12/13) signalling events.)
R-HSA-416572 (Sema4D induced cell migration and growth-cone collapse.)
R-HSA-4420097 (VEGFA-VEGFR2 Pathway.)
R-HSA-5627117 (RHO GTPases Activate ROCKs.)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt B0YJ91 Q13464 Q2KHM4 Q59GZ4

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR001849 (PH_domain.)
IPR002219 (PE/DAG-bd.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR011993 (PH_dom-like.)
IPR015008 (Rho-bd_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020684 (ROCK1/ROCK2.)
IPR029876 (ROCK1.)
Pfam PF00069 (Pkinase)
PF08912 (Rho_Binding)

Target Cross References - Structure

PDBe 1S1C 2ESM 2ETK 2ETR 2V55 3D9V 3NCZ 3NDM 3O0Z 3TV7 3TWJ 3V8S 4L2W 4W7P 4YVC 4YVE 5BML 5F5P
CREDO 1S1C 2ESM 2ETK 2ETR 2V55 3D9V 3NCZ 3NDM 3O0Z 3TV7 3TWJ 3V8S 4L2W 4W7P 4YVC 4YVE 5BML 5F5P
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