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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3219
Target Type SINGLE PROTEIN
Preferred Name Cholesterol esterase
Synonyms BAL | BAL | BSSL | Bile salt-activated lipase | Bile salt-stimulated lipase | Bucelipase | CEL | Carboxyl ester lipase | Cholesterol esterase | Pancreatic lysophospholipase | Sterol esterase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Bile salt-activated lipase SINGLE PROTEIN P19835

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000170835
Ensembl ENSG00000170835
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0045202 (synapse)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004771 (sterol esterase activity)
GO:0004806 (triglyceride lipase activity)
GO:0004872 (receptor activity)
GO:0005515 (protein binding)
GO:0008201 (heparin binding)
GO:0016787 (hydrolase activity)
GO:0042043 (neurexin family protein binding)
GO:0047372 (acylglycerol lipase activity)
GO:0052689 (carboxylic ester hydrolase activity)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006641 (triglyceride metabolic process)
GO:0006707 (cholesterol catabolic process)
GO:0007158 (neuron cell-cell adhesion)
GO:0007416 (synapse assembly)
GO:0009062 (fatty acid catabolic process)
GO:0016042 (lipid catabolic process)
GO:0018350 (protein esterification)
GO:0030157 (pancreatic juice secretion)
GO:0030299 (intestinal cholesterol absorption)
GO:0044241 (lipid digestion)
GO:0044258 (intestinal lipid catabolic process)
GO:0050804 (modulation of synaptic transmission)
Wikipedia Bile_salt-dependent_lipase

Target Cross References - Protein

canSAR P19835
Human Protein Atlas ENSG00000170835
IntAct P19835
Open Targets ENSG00000170835
PharmGKB PA26391
Reactome R-HSA-192456 (Digestion of dietary lipid.)
UniProt P19835 Q16398 Q5T7U7 Q9UCH1 Q9UP41

Target Cross References - Domain

InterPro IPR002018 (CarbesteraseB.)
IPR019819 (Carboxylesterase_B_CS.)
IPR019826 (Carboxylesterase_B_AS.)
IPR029058 (AB_hydrolase.)
IPR032059 (Mucin-like.)
IPR033560 (BAL.)
Pfam PF00135 (COesterase)
PF16058 (Mucin-like)

Target Cross References - Structure

PDBe 1F6W 1JMY
CREDO 1F6W 1JMY
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