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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3218
Target Type SINGLE PROTEIN
Preferred Name CD22
Synonyms B-cell receptor CD22 | B-lymphocyte cell adhesion molecule | BL-CAM | CD22 | CD_antigen=CD22 | SIGLEC2 | Sialic acid-binding Ig-like lectin 2 | Siglec-2 | T-cell surface antigen Leu-14
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor
  • surface antigen
  • adhesion

Target Components

Component Description Relationship Accession
B-cell receptor CD22 SINGLE PROTEIN P20273

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1743043 MOXETUMOMAB PASUDOTOX CD22 other 3 PubMed
CHEMBL2108228 BECTUMOMAB CD22 other 3 PubMed
CHEMBL2108611 INOTUZUMAB OZOGAMICIN CD22 binding agent 3 PubMed
CHEMBL2109352 CAT-3888 CD22 binding agent 2 Other

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000012124
Ensembl ENSG00000012124
GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0005515 (protein binding)
GO:0030246 (carbohydrate binding)
GO Biological Process GO:0007155 (cell adhesion)
Wikipedia CD22

Target Cross References - Protein

canSAR P20273
Human Protein Atlas ENSG00000012124
IntAct P20273
Guide to Pharmacology 2786
Open Targets ENSG00000012124
PharmGKB PA26201
Reactome R-HSA-198933 (Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.)
R-HSA-5690714 (CD22 mediated BCR regulation.)
R-HSA-983695 (Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.)
UniProt F5GYU4 F5H7U3 O95699 O95701 O95702 O95703 P20273 Q01665 Q32M46 Q92872 Q92873 Q9UQA6 Q9UQA7 Q9UQA8 Q9UQA9 Q9UQB0 Q9Y2A6

Target Cross References - Domain

InterPro IPR003598 (Ig_sub2.)
IPR003599 (Ig_sub.)
IPR007110 (Ig-like_dom.)
IPR013162 (CD80_C2-set.)
IPR013783 (Ig-like_fold.)
Pfam PF08205 (C2-set_2)
PF13895 (Ig_2)
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