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Target Report Card

Target Name and Classification

Target ID CHEMBL3213
Preferred Name Calcium-independent phospholipase A2
Synonyms 85/88 kDa calcium-independent phospholipase A2 | CaI-PLA2 | GVI PLA2 | Group VI phospholipase A2 | Intracellular membrane-associated calcium-independent phospholipase A2 beta | PLA2G6 | PLPLA9 | PNPLA9 | Patatin-like phospholipase domain-containing protein 9 | iPLA2-beta
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
85/88 kDa calcium-independent phospholipase A2 SINGLE PROTEIN O60733

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000184381
Ensembl ENSG00000184381
GO Cellular Component GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005815 (microtubule organizing center)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO Molecular Function GO:0004623 (phospholipase A2 activity)
GO:0005516 (calmodulin binding)
GO:0016787 (hydrolase activity)
GO:0019901 (protein kinase binding)
GO:0043008 (ATP-dependent protein binding)
GO:0047499 (calcium-independent phospholipase A2 activity)
GO Biological Process GO:0001934 (positive regulation of protein phosphorylation)
GO:0006629 (lipid metabolic process)
GO:0006935 (chemotaxis)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007613 (memory)
GO:0008152 (metabolic process)
GO:0014832 (urinary bladder smooth muscle contraction)
GO:0016042 (lipid catabolic process)
GO:0019731 (antibacterial humoral response)
GO:0032049 (cardiolipin biosynthetic process)
GO:0034976 (response to endoplasmic reticulum stress)
GO:0035774 (positive regulation of insulin secretion involved in cellular response to glucose stimulus)
GO:0036151 (phosphatidylcholine acyl-chain remodeling)
GO:0036152 (phosphatidylethanolamine acyl-chain remodeling)
GO:0038096 (Fc-gamma receptor signaling pathway involved in phagocytosis)
GO:0045909 (positive regulation of vasodilation)
GO:0045921 (positive regulation of exocytosis)
GO:0051967 (negative regulation of synaptic transmission, glutamatergic)
GO:0060135 (maternal process involved in female pregnancy)
GO:0090037 (positive regulation of protein kinase C signaling)
GO:0090200 (positive regulation of release of cytochrome c from mitochondria)
GO:0090238 (positive regulation of arachidonic acid secretion)
GO:1901339 (regulation of store-operated calcium channel activity)
GO:2000304 (positive regulation of ceramide biosynthetic process)
Wikipedia PLA2G6

Target Cross References - Protein

canSAR O60733
CGD Parkinson disease 14, autosomal recessive; Neurodegeneration with brain iron accumulation 2A; Neurodegeneration with brain iron accumulation 2B
Human Protein Atlas ENSG00000184381
IntAct O60733
Open Targets ENSG00000184381
PharmGKB PA33367
Reactome R-HSA-1482788 (Acyl chain remodelling of PC.)
R-HSA-1482798 (Acyl chain remodeling of CL.)
R-HSA-1482839 (Acyl chain remodelling of PE.)
R-HSA-2029485 (Role of phospholipids in phagocytosis.)
R-HSA-6811436 (COPI-independent Golgi-to-ER retrograde traffic.)
UniProt A8K597 B0QYE8 O60733 O75645 Q8N452 Q9UG29 Q9UIT0 Q9Y671

Target Cross References - Domain

InterPro IPR002110 (Ankyrin_rpt.)
IPR002641 (Patatin/PLipase_A2-rel.)
IPR016035 (Acyl_Trfase/lysoPLipase.)
IPR020683 (Ankyrin_rpt-contain_dom.)
Pfam PF01734 (Patatin)
PF12796 (Ank_2)