ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL3200
Target Type SINGLE PROTEIN
Preferred Name Sialidase 2
Synonyms Cytosolic sialidase | N-acetyl-alpha-neuraminidase 2 | NEU2 | Sialidase-2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Sialidase-2 SINGLE PROTEIN Q9Y3R4

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000115488
Ensembl ENSG00000115488
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004308 (exo-alpha-sialidase activity)
GO:0005515 (protein binding)
GO:0016787 (hydrolase activity)
GO:0016798 (hydrolase activity, acting on glycosyl bonds)
GO:0052794 (exo-alpha-(2->3)-sialidase activity)
GO:0052795 (exo-alpha-(2->6)-sialidase activity)
GO:0052796 (exo-alpha-(2->8)-sialidase activity)
GO Biological Process GO:0005975 (carbohydrate metabolic process)
GO:0006629 (lipid metabolic process)
GO:0006687 (glycosphingolipid metabolic process)
GO:0006689 (ganglioside catabolic process)
GO:0008152 (metabolic process)
GO:0009313 (oligosaccharide catabolic process)
GO:0010831 (positive regulation of myotube differentiation)
GO:0016042 (lipid catabolic process)
GO:0045471 (response to ethanol)
GO:0045663 (positive regulation of myoblast differentiation)
Wikipedia NEU2

Target Cross References - Protein

canSAR Q9Y3R4
Human Protein Atlas ENSG00000115488
IntAct Q9Y3R4
Open Targets ENSG00000115488
PharmGKB PA31561
Reactome R-HSA-1660662 (Glycosphingolipid metabolism.)
R-HSA-4085001 (Sialic acid metabolism.)
UniProt Q3KNW4 Q6NTB4 Q9Y3R4

Target Cross References - Domain

InterPro IPR011040 (Sialidases.)
IPR026856 (Sialidase_fam.)
IPR026945 (Sialidase-2.)
Pfam PF13088 (BNR_2)

Target Cross References - Structure

PDBe 1SNT 1SO7 1VCU 2F0Z 2F10 2F11 2F12 2F13 2F24 2F25 2F26 2F27 2F28 2F29 4NC5 4NCS
CREDO 1SNT 1SO7 1VCU 2F0Z 2F10 2F11 2F12 2F13 2F24 2F25 2F26 2F27 2F28 2F29 4NC5 4NCS
spacer
spacer