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Target Report Card

Target Name and Classification

Target ID CHEMBL3182
Preferred Name Prohormone convertase 1
Synonyms NEC 1 | NEC1 | Neuroendocrine convertase 1 | PC1 | PCSK1 | Prohormone convertase 1 | Proprotein convertase 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease sb clan > serine protease s8b subfamily

Target Components

Component Description Relationship Accession
Neuroendocrine convertase 1 SINGLE PROTEIN P29120

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000175426
Ensembl ENSG00000175426
GO Cellular Component GO:0005615 (extracellular space)
GO:0030133 (transport vesicle)
GO:0031410 (cytoplasmic vesicle)
GO:0034774 (secretory granule lumen)
GO Molecular Function GO:0004175 (endopeptidase activity)
GO:0004252 (serine-type endopeptidase activity)
GO:0008233 (peptidase activity)
GO:0008236 (serine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO Biological Process GO:0006508 (proteolysis)
GO:0007267 (cell-cell signaling)
GO:0008152 (metabolic process)
GO:0016485 (protein processing)
GO:0016486 (peptide hormone processing)
GO:0043043 (peptide biosynthetic process)
Wikipedia Proprotein_convertase_1

Target Cross References - Protein

canSAR P29120
CGD Proprotein convertase 1/3 deficiency
Human Protein Atlas ENSG00000175426
IntAct P29120
Guide to Pharmacology 2382
Open Targets ENSG00000175426
PharmGKB PA33089
Reactome R-HSA-209952 (Peptide hormone biosynthesis.)
R-HSA-264876 (Insulin processing.)
R-HSA-381771 (Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).)
R-HSA-400511 (Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).)
R-HSA-422085 (Synthesis, secretion, and deacylation of Ghrelin.)
UniProt B7Z8T7 E9PHA1 P29120 P78478 Q92532

Target Cross References - Domain

InterPro IPR000209 (Peptidase_S8/S53_dom.)
IPR002884 (PrprotnconvertsP.)
IPR008979 (Galactose-bd-like.)
IPR009020 (Propept_inh.)
IPR015500 (Peptidase_S8_subtilisin-rel.)
IPR022005 (Proho_convert.)
IPR022398 (Peptidase_S8_His-AS.)
IPR023827 (Peptidase_S8_Asp-AS.)
IPR023828 (Peptidase_S8_Ser-AS.)
IPR032815 (S8_pro-domain.)
IPR034182 (Kexin/furin.)
Pfam PF00082 (Peptidase_S8)
PF01483 (P_proprotein)
PF12177 (Proho_convert)
PF16470 (S8_pro-domain)