ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL3181
Target Type SINGLE PROTEIN
Preferred Name Estradiol 17-beta-dehydrogenase 1
Synonyms 17-beta-HSD 1 | 17-beta-hydroxysteroid dehydrogenase type 1 | 20 alpha-hydroxysteroid dehydrogenase | 20-alpha-HSD | E17KSR | E2DH | EDH17B1 | EDH17B2 | EDHB17 | Estradiol 17-beta-dehydrogenase 1 | HSD17B1 | Placental 17-beta-hydroxysteroid dehydrogenase | SDR28C1 | Short chain dehydrogenase/reductase family 28C member 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Estradiol 17-beta-dehydrogenase 1 SINGLE PROTEIN P14061

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000108786
Ensembl ENSG00000108786
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0031965 (nuclear membrane)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004303 (estradiol 17-beta-dehydrogenase activity)
GO:0016491 (oxidoreductase activity)
GO:0047035 (testosterone dehydrogenase (NAD+) activity)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006694 (steroid biosynthetic process)
GO:0006703 (estrogen biosynthetic process)
GO:0008210 (estrogen metabolic process)
GO:0055114 (oxidation-reduction process)
GO:0060348 (bone development)
GO:0061370 (testosterone biosynthetic process)
GO:0071248 (cellular response to metal ion)
Wikipedia HSD17B1

Target Cross References - Protein

Human Protein Atlas ENSG00000108786
IntAct P14061
Open Targets ENSG00000108786
PharmGKB PA29478
Reactome R-HSA-193144 (Estrogen biosynthesis.)
R-HSA-2453902 (The canonical retinoid cycle in rods (twilight vision).)
UniProt B3KXS1 P14061 Q2M2L8

Target Cross References - Domain

InterPro IPR002347 (SDR_fam.)
IPR011348 (17beta_DH.)
IPR016040 (NAD(P)-bd_dom.)
IPR020904 (Sc_DH/Rdtase_CS.)
Pfam PF00106 (adh_short)

Target Cross References - Structure

PDBe 1A27 1BHS 1DHT 1EQU 1FDS 1FDT 1FDU 1FDV 1FDW 1I5R 1IOL 1JTV 1QYV 1QYW 1QYX 3DEY 3DHE 3HB4 3HB5 3KLM 3KLP 3KM0
CREDO 1A27 1BHS 1DHT 1EQU 1FDS 1FDT 1FDU 1FDV 1FDW 1I5R 1IOL 1JTV 1QYV 1QYW 1QYX 3DEY 3DHE 3HB4 3HB5 3KLM 3KLP 3KM0
spacer
spacer