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Target Report Card

Target Name and Classification

Target ID CHEMBL3179
Target Type SINGLE PROTEIN
Preferred Name Tyrosyl-tRNA synthetase
Synonyms TyrRS | Tyrosine--tRNA ligase, cytoplasmic | Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed | Tyrosyl-tRNA synthetase | YARS
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Tyrosine--tRNA ligase, cytoplasmic SINGLE PROTEIN P54577

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000134684
Ensembl ENSG00000134684
GO Cellular Component GO:0005615 (extracellular space)
GO:0005625 (soluble fraction)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0000049 (tRNA binding)
GO:0004831 (tyrosine-tRNA ligase activity)
GO:0004871 (signal transducer activity)
GO:0005153 (interleukin-8 receptor binding)
GO:0005524 (ATP binding)
GO:0044822 (poly(A) RNA binding)
GO Biological Process GO:0006418 (tRNA aminoacylation for protein translation)
GO:0006437 (tyrosyl-tRNA aminoacylation)
GO:0006915 (apoptosis)
GO:0006915 (apoptotic process)
GO:0007165 (signal transduction)
GO:0010467 (gene expression)
Wikipedia YARS

Target Cross References - Protein

canSAR P54577
CGD Charcot-Marie-Tooth disease, dominant intermediate C
Human Protein Atlas ENSG00000134684
IntAct P54577
PharmGKB PA37431
UniProt B3KWK4 D3DPQ4 O43276 P54577 Q53EN1

Target Cross References - Domain

InterPro IPR002305 (Aminoacyl-tRNA-synth_Ib.)
IPR002305 (aa-tRNA-synth_Ic.)
IPR002307 (Tyr-tRNA-ligase.)
IPR002307 (Tyr-tRNA-synth_Ib.)
IPR002547 (tRNA-bd_dom.)
IPR012340 (NA-bd_OB-fold.)
IPR014729 (Rossmann-like_a/b/a_fold.)
IPR016027 (NA-bd_OB-fold-like.)
IPR023617 (Tyr-tRNA-synth_Ib_euk/arc.)
Pfam PF00579 (tRNA-synt_1b)
PF01588 (tRNA_bind)

Target Cross References - Structure

PDBe 1N3L 1NTG 1Q11 4Q93 4QBT
CREDO 1N3L 1NTG 1Q11 4Q93 4QBT
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