ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL3176
Target Type SINGLE PROTEIN
Preferred Name Galanin receptor 2
Synonyms GAL2-R | GALNR2 | GALR-2 | GALR2 | Galanin receptor type 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > galanin receptor

Target Components

Component Description Relationship Accession
Galanin receptor type 2 SINGLE PROTEIN O43603

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000182687
Ensembl ENSG00000182687
GO Cellular Component GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004966 (galanin receptor activity)
GO:0005515 (protein binding)
GO:0017046 (peptide hormone binding)
GO:0042923 (neuropeptide binding)
GO Biological Process GO:0006936 (muscle contraction)
GO:0007165 (signal transduction)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007188 (adenylate cyclase-modulating G-protein coupled receptor signaling pathway)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007194 (negative regulation of adenylate cyclase activity)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007218 (neuropeptide signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0007275 (multicellular organism development)
GO:0007586 (digestion)
GO:0007611 (learning or memory)
GO:0007631 (feeding behavior)
GO:0031175 (neuron projection development)
GO:0043647 (inositol phosphate metabolic process)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046488 (phosphatidylinositol metabolic process)
GO:1902608 (positive regulation of large conductance calcium-activated potassium channel activity)
Wikipedia Galanin_receptor_2

Target Cross References - Protein

canSAR O43603
Human Protein Atlas ENSG00000182687
IntAct O43603
Guide to Pharmacology 244
Open Targets ENSG00000182687
PharmGKB PA28546
Pharos O43603 (Tchem)
Reactome R-HSA-375276 (Peptide ligand-binding receptors.)
R-HSA-418594 (G alpha (i) signalling events.)
UniProt A5JUU4 O43603 Q32MN8

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000405 (Galanin_rcpt.)
IPR003907 (GAL2_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
spacer
spacer