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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3174
Target Type SINGLE PROTEIN
Preferred Name Glutathione transferase omega 1
Synonyms GSTO 1-1 | GSTO-1 | GSTO1 | GSTTLP28 | Glutathione S-transferase omega 1-1 | Glutathione S-transferase omega-1 | Glutathione-dependent dehydroascorbate reductase | MMA(V) reductase | Monomethylarsonic acid reductase | S-(Phenacyl)glutathione reductase | SPG-R
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Glutathione S-transferase omega-1 SINGLE PROTEIN P78417

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000148834
Ensembl ENSG00000148834
GO Cellular Component GO:0005604 (basement membrane)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0030424 (axon)
GO:0031965 (nuclear membrane)
GO:0043209 (myelin sheath)
GO:0044297 (cell body)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004364 (glutathione transferase activity)
GO:0005515 (protein binding)
GO:0016491 (oxidoreductase activity)
GO:0016740 (transferase activity)
GO:0045174 (glutathione dehydrogenase (ascorbate) activity)
GO:0050610 (methylarsonate reductase activity)
GO Biological Process GO:0006749 (glutathione metabolic process)
GO:0008152 (metabolic process)
GO:0010880 (regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)
GO:0010881 (regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)
GO:0014810 (positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion)
GO:0019852 (L-ascorbic acid metabolic process)
GO:0019853 (L-ascorbic acid biosynthetic process)
GO:0032259 (methylation)
GO:0042178 (xenobiotic catabolic process)
GO:0055114 (oxidation-reduction process)
GO:0060315 (negative regulation of ryanodine-sensitive calcium-release channel activity)
GO:0060316 (positive regulation of ryanodine-sensitive calcium-release channel activity)
GO:0071243 (cellular response to arsenic-containing substance)
GO:0098869 (cellular oxidant detoxification)
GO:1901687 (glutathione derivative biosynthetic process)
Wikipedia GSTO1

Target Cross References - Protein

canSAR P78417
Human Protein Atlas ENSG00000148834
IntAct P78417
Open Targets ENSG00000148834
PharmGKB PA133787054
Reactome R-HSA-156581 (Methylation.)
R-HSA-156590 (Glutathione conjugation.)
R-HSA-196836 (Vitamin C (ascorbate) metabolism.)
UniProt D3DRA3 F5H7H0 P78417 Q5TA03 Q7Z3T2

Target Cross References - Domain

InterPro IPR004045 (Glutathione_S-Trfase_N.)
IPR004046 (GST_C.)
IPR005442 (GST_omega.)
IPR010987 (Glutathione-S-Trfase_C-like.)
IPR012336 (Thioredoxin-like_fold.)
Pfam PF13417 (GST_N_3)
PF14497 (GST_C_3)

Target Cross References - Structure

PDBe 1EEM 3LFL 3VLN 4IS0 4YQM 4YQU 4YQV
CREDO 1EEM 3LFL 3VLN 4IS0 4YQM 4YQU 4YQV
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