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Target Report Card

Target Name and Classification

Target ID CHEMBL3167
Preferred Name Serum paraoxonase/arylesterase 1
Synonyms A-esterase 1 | Aromatic esterase 1 | K-45 | PON 1 | PON | PON1 | Serum aryldialkylphosphatase 1 | Serum paraoxonase/arylesterase 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Serum paraoxonase/arylesterase 1 SINGLE PROTEIN P27169

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000005421
Ensembl ENSG00000005421
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0034364 (high-density lipoprotein particle)
GO:0034366 (spherical high-density lipoprotein particle)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0070062 (extracellular exosome)
GO:0072562 (blood microparticle)
GO Molecular Function GO:0004063 (aryldialkylphosphatase activity)
GO:0004064 (arylesterase activity)
GO:0005509 (calcium ion binding)
GO:0005543 (phospholipid binding)
GO:0016787 (hydrolase activity)
GO:0042803 (protein homodimerization activity)
GO:0046872 (metal ion binding)
GO:0102007 (acyl-L-homoserine-lactone lactonohydrolase activity)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0008203 (cholesterol metabolic process)
GO:0009605 (response to external stimulus)
GO:0009636 (response to toxic substance)
GO:0010875 (positive regulation of cholesterol efflux)
GO:0016311 (dephosphorylation)
GO:0019439 (aromatic compound catabolic process)
GO:0031667 (response to nutrient levels)
GO:0032411 (positive regulation of transporter activity)
GO:0034445 (negative regulation of plasma lipoprotein particle oxidation)
GO:0046395 (carboxylic acid catabolic process)
GO:0046434 (organophosphate catabolic process)
GO:0046470 (phosphatidylcholine metabolic process)
GO:0051099 (positive regulation of binding)
GO:0070542 (response to fatty acid)
GO:1902617 (response to fluoride)
Wikipedia PON1

Target Cross References - Protein

CGD Clopidogrel treatment, sensitivity to
Human Protein Atlas ENSG00000005421
Open Targets ENSG00000005421
PharmGKB PA33529
Reactome R-HSA-2142688 (Synthesis of 5-eicosatetraenoic acids.)
UniProt B2RA40 P27169 Q16052 Q6B0J6 Q9UCB1

Target Cross References - Domain

InterPro IPR002640 (Arylesterase.)
IPR008363 (Paraoxonase1.)
IPR011042 (6-blade_b-propeller_TolB-like.)
Pfam PF01731 (Arylesterase)

Target Cross References - Structure

PDBe 1V04