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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3161
Target Type SINGLE PROTEIN
Preferred Name Leukocyte adhesion molecule-1
Synonyms CD62 antigen-like family member L | CD_antigen=CD62L | L-selectin | LAM-1 | LECAM1 | LNHR | LYAM1 | Leukocyte adhesion molecule 1 | Leukocyte surface antigen Leu-8 | Leukocyte-endothelial cell adhesion molecule 1 | Lymph node homing receptor | SELL | TQ1 | gp90-MEL
Organism Homo sapiens
Species Group No
Protein Target Classification
  • adhesion

Target Components

Component Description Relationship Accession
L-selectin SINGLE PROTEIN P14151

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3831288 Selectin PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3707446 RIVIPANSEL Leukocyte adhesion molecule-1 antagonist 3 PubMed
CHEMBL2108575 ASELIZUMAB Leukocyte adhesion molecule-1 inhibitor 2 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000188404
Ensembl ENSG00000188404
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030667 (secretory granule membrane)
GO Molecular Function GO:0002020 (protease binding)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0008201 (heparin binding)
GO:0030246 (carbohydrate binding)
GO:0043208 (glycosphingolipid binding)
GO:0046872 (metal ion binding)
GO:0050839 (cell adhesion molecule binding)
GO:0070492 (oligosaccharide binding)
GO Biological Process GO:0007155 (cell adhesion)
GO:0016339 (calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)
GO:0033198 (response to ATP)
GO:0043312 (neutrophil degranulation)
GO:0050776 (regulation of immune response)
GO:0050900 (leukocyte migration)
GO:0050901 (leukocyte tethering or rolling)
Wikipedia L-selectin

Target Cross References - Protein

canSAR P14151
Human Protein Atlas ENSG00000188404
Open Targets ENSG00000188404
PharmGKB PA35642
Reactome R-HSA-198933 (Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.)
R-HSA-202733 (Cell surface interactions at the vascular wall.)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt A0A024R8Z0 B2R6Q8 P14151 P15023 Q9UJ43

Target Cross References - Domain

InterPro IPR000436 (Sushi_SCR_CCP_dom.)
IPR000742 (EGF-like_dom.)
IPR001304 (C-type_lectin-like.)
IPR002396 (Selectin_superfamily.)
IPR013032 (EGF-like_CS.)
IPR016186 (C-type_lectin-like/link_sf.)
IPR016187 (CTDL_fold.)
IPR016348 (L-selectin.)
IPR018378 (C-type_lectin_CS.)
IPR033991 (Selectin_CTLD.)
IPR035976 (Sushi/SCR/CCP_sf.)
Pfam PF00059 (Lectin_C)
PF00084 (Sushi)

Target Cross References - Structure

PDBe 3CFW 5VC1
CREDO 3CFW 5VC1
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