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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3143
Target Type SINGLE PROTEIN
Preferred Name Coagulation factor VIII
Synonyms AHF | Antihemophilic factor | Coagulation factor VIII | F8 | F8C | Factor VIII B chain | Factor VIIIa heavy chain, 200 kDa isoform | Factor VIIIa heavy chain, 92 kDa isoform | Factor VIIIa light chain | Procoagulant component
Organism Homo sapiens
Species Group No
Protein Target Classification
  • secreted protein

Target Components

Component Description Relationship Accession
Coagulation factor VIII SINGLE PROTEIN P00451

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2109065 DROTRECOGIN ALFA (ACTIVATED) Coagulation factor VIII inhibitor 4 DailyMed
CHEMBL2109410 TB-402 Coagulation factor VIII inhibitor 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000185010
Ensembl ENSG00000185010
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005886 (plasma membrane)
GO:0030134 (ER to Golgi transport vesicle)
GO:0031093 (platelet alpha granule lumen)
GO:0033116 (endoplasmic reticulum-Golgi intermediate compartment membrane)
GO Molecular Function GO:0005507 (copper ion binding)
GO:0005515 (protein binding)
GO:0016491 (oxidoreductase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0002576 (platelet degranulation)
GO:0006888 (ER to Golgi vesicle-mediated transport)
GO:0006953 (acute-phase response)
GO:0007596 (blood coagulation)
GO:0007597 (blood coagulation, intrinsic pathway)
GO:0007599 (hemostasis)
GO:0030168 (platelet activation)
GO:0048208 (COPII vesicle coating)
GO:0055114 (oxidation-reduction process)
Wikipedia Factor_VIII

Target Cross References - Protein

canSAR P00451
CGD Hemophilia A
Human Protein Atlas ENSG00000185010
IntAct P00451
Open Targets ENSG00000185010
PharmGKB PA27952
Reactome R-HSA-114608 (Platelet degranulation.)
R-HSA-140837 (Intrinsic Pathway of Fibrin Clot Formation.)
R-HSA-140875 (Common Pathway of Fibrin Clot Formation.)
R-HSA-204005 (COPII (Coat Protein 2) Mediated Vesicle Transport.)
R-HSA-5694530 (Cargo concentration in the ER.)
UniProt P00451 Q14286 Q5HY69

Target Cross References - Domain

InterPro IPR000421 (FA58C.)
IPR001117 (Cu-oxidase.)
IPR008972 (Cupredoxin.)
IPR008979 (Galactose-bd-like.)
IPR011706 (Cu-oxidase_2.)
IPR011707 (Cu-oxidase_3.)
IPR014707 (Factor_8.)
IPR024715 (Factor_5/8.)
IPR033138 (Cu_oxidase_CS.)
Pfam PF00394 (Cu-oxidase)
PF00754 (F5_F8_type_C)
PF07731 (Cu-oxidase_2)
PF07732 (Cu-oxidase_3)

Target Cross References - Structure

PDBe 1D7P 1IQD 2R7E 3CDZ 3HNB 3HNY 3HOB 4BDV 4KI5 4PT6 4XZU
CREDO 1D7P 1IQD 2R7E 3CDZ 3HNB 3HNY 3HOB 4BDV 4KI5 4PT6 4XZU
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