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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3133
Target Type SINGLE PROTEIN
Preferred Name Sodium/hydrogen exchanger 2
Synonyms NHE-2 | NHE2 | Na(+)/H(+) exchanger 2 | SLC9A2 | Sodium/hydrogen exchanger 2 | Solute carrier family 9 member 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc09 family of sodium/hydrogen exchangers

Target Components

Component Description Relationship Accession
Sodium/hydrogen exchanger 2 SINGLE PROTEIN Q9UBY0

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000115616
Ensembl ENSG00000115616
GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0015297 (antiporter activity)
GO:0015299 (solute:proton antiporter activity)
GO:0015385 (sodium:proton antiporter activity)
GO:0015386 (potassium:proton antiporter activity)
GO Biological Process GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006812 (cation transport)
GO:0006814 (sodium ion transport)
GO:0006885 (regulation of pH)
GO:0008104 (protein localization)
GO:0035725 (sodium ion transmembrane transport)
GO:0051453 (regulation of intracellular pH)
GO:0055085 (transmembrane transport)
GO:0071805 (potassium ion transmembrane transport)
GO:0098719 (sodium ion import across plasma membrane)
GO:1902600 (hydrogen ion transmembrane transport)
Wikipedia SLC9A2

Target Cross References - Protein

canSAR Q9UBY0
Human Protein Atlas ENSG00000115616
IntAct Q9UBY0
Open Targets ENSG00000115616
PharmGKB PA35929
Reactome R-HSA-425986 (Sodium/Proton exchangers.)
UniProt B2RMS2 Q9UBY0

Target Cross References - Domain

InterPro IPR001953 (Na/H_exchanger_2.)
IPR004709 (NaH_exchanger.)
IPR006153 (Cation/H_exchanger.)
IPR018422 (Cation/H_exchanger_CPA1.)
IPR032103 (NHE_CaM-bd.)
Pfam PF00999 (Na_H_Exchanger)
PF16644 (NEXCaM_BD)
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