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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3132
Target Type SINGLE PROTEIN
Preferred Name Alpha-galactosidase B
Synonyms Alpha-N-acetylgalactosaminidase | Alpha-galactosidase B | NAGA
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Alpha-N-acetylgalactosaminidase SINGLE PROTEIN P17050

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000198951
Ensembl ENSG00000198951
GO Cellular Component GO:0070062 (extracellular exosome)
GO:0005737 (cytoplasm)
GO:0005764 (lysosome)
GO Molecular Function GO:0004557 (alpha-galactosidase activity)
GO:0008456 (alpha-N-acetylgalactosaminidase activity)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0019377 (glycolipid catabolic process)
GO:0009311 (oligosaccharide metabolic process)
GO:0016052 (carbohydrate catabolic process)
GO:0046477 (glycosylceramide catabolic process)
GO:0016139 (glycoside catabolic process)
Wikipedia NAGA_(gene)

Target Cross References - Protein

canSAR P17050
CGD Kanzaki disease; Alpha-n-acetylgalactosaminidase deficiency; Schindler disease type I; Schindler disease type III
Human Protein Atlas ENSG00000198951
PharmGKB PA31435
UniProt P17050

Target Cross References - Domain

InterPro IPR013780 (Glyco_hydro_13_b.)
IPR017853 (Glycoside_hydrolase_SF.)
IPR013785 (Aldolase_TIM.)
IPR000111 (Glyco_hydro_27/36_CS.)
IPR002241 (Glyco_hydro_27.)
Pfam PF16499 (Melibiase_2)

Target Cross References - Structure

PDBe 4DO5 3H54 4DO6 3IGU 3H55 4DO4 3H53
CREDO 4DO5 3H54 4DO6 3IGU 3H55 4DO4 3H53
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