ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL3123
Target Type SINGLE PROTEIN
Preferred Name Death-associated protein kinase 2
Synonyms DAP kinase 2 | DAP-kinase-related protein 1 | DAPK2 | DRP-1 | Death-associated protein kinase 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase dapk family

Target Components

Component Description Relationship Accession
Death-associated protein kinase 2 SINGLE PROTEIN Q9UIK4

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000035664
Ensembl ENSG00000035664
GO Cellular Component GO:0005737 (cytoplasm)
GO:0031410 (cytoplasmic vesicle)
GO:0034423 (autophagosome lumen)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005516 (calmodulin binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0042802 (identical protein binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0010506 (regulation of autophagy)
GO:0016310 (phosphorylation)
GO:0035556 (intracellular signal transduction)
GO:0042981 (regulation of apoptotic process)
GO:0043276 (anoikis)
GO:0046777 (protein autophosphorylation)
GO:0090023 (positive regulation of neutrophil chemotaxis)
GO:1990266 (neutrophil migration)
GO:2000424 (positive regulation of eosinophil chemotaxis)
GO:2001242 (regulation of intrinsic apoptotic signaling pathway)
Wikipedia DAPK2

Target Cross References - Protein

canSAR Q9UIK4
Human Protein Atlas ENSG00000035664
IntAct Q9UIK4
Guide to Pharmacology 2003
Open Targets ENSG00000035664
PharmGKB PA27143
Pharos Q9UIK4 (Tchem)
Reactome R-HSA-418889 (Ligand-independent caspase activation via DCC.)
UniProt E9JGM7 O75892 Q24JS1 Q9UIK4

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020636 (Ca/CaM-dep_Ca-dep_prot_Kinase.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 1WMK 1WRZ 1Z9X 1ZUZ 1ZWS 2A27 2A2A 2CKE
CREDO 1WMK 1WRZ 1Z9X 1ZUZ 1ZWS 2A27 2A2A 2CKE
spacer
spacer