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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3117
Target Type SINGLE PROTEIN
Preferred Name Choline kinase alpha
Synonyms CHETK-alpha | CHK | CHKA | CK | CKI | Choline kinase alpha | EK | Ethanolamine kinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Choline kinase alpha SINGLE PROTEIN P35790

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3545084 TCD-717 Choline kinase alpha inhibitor 1

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000110721
Ensembl ENSG00000110721
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004103 (choline kinase activity)
GO:0004104 (cholinesterase activity)
GO:0004305 (ethanolamine kinase activity)
GO:0004871 (signal transducer activity)
GO:0005524 (ATP binding)
GO:0008144 (drug binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0033265 (choline binding)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0006580 (ethanolamine metabolic process)
GO:0006629 (lipid metabolic process)
GO:0006646 (phosphatidylethanolamine biosynthetic process)
GO:0006656 (phosphatidylcholine biosynthetic process)
GO:0006657 (CDP-choline pathway)
GO:0006869 (lipid transport)
GO:0007165 (signal transduction)
GO:0008654 (phospholipid biosynthetic process)
GO:0009636 (response to toxic substance)
GO:0016310 (phosphorylation)
GO:0019695 (choline metabolic process)
GO:1904681 (response to 3-methylcholanthrene)
Wikipedia CHKA

Target Cross References - Protein

canSAR P35790
Human Protein Atlas ENSG00000110721
IntAct P35790
MICAD NBK23549 (Choline kinase)
Open Targets ENSG00000110721
PharmGKB PA26468
Pharos P35790 (Tbio)
Reactome R-HSA-1483191 (Synthesis of PC.)
R-HSA-1483213 (Synthesis of PE.)
UniProt P35790 Q8NE29

Target Cross References - Domain

InterPro IPR011009 (Kinase-like_dom.)

Target Cross References - Structure

PDBe 2CKO 2CKP 2CKQ 2I7Q 3F2R 3G15 3ZM9 4BR3 4CG8 4CG9 4CGA 4DA5 5AFV 5EQE 5EQP 5EQY 5FTG 5FUT
CREDO 2CKO 2CKP 2CKQ 2I7Q 3F2R 3G15 3ZM9 4BR3 4CG8 4CG9 4CGA 4DA5 5AFV 5EQE 5EQP 5EQY 5FTG 5FUT
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