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Target Report Card

Target Name and Classification

Target ID CHEMBL3116
Target Type SINGLE PROTEIN
Preferred Name Cyclin-dependent kinase 9
Synonyms C-2K | CDC2L4 | CDK9 | Cell division cycle 2-like protein kinase 4 | Cell division protein kinase 9 | Cyclin-dependent kinase 9 | Serine/threonine-protein kinase PITALRE | TAK | Tat-associated kinase complex catalytic subunit
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase cdk family > cmgc protein kinase cdk9 subfamily

Target Components

Component Description Relationship Accession
Cyclin-dependent kinase 9 SINGLE PROTEIN P50750

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111389 CDK9/cyclin T1 PROTEIN COMPLEX
CHEMBL3559691 Cyclin-dependent kinase PROTEIN FAMILY
CHEMBL3038475 CDK9/Cyclin K PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL428690 ALVOCIDIB Cyclin-dependent kinase 9 inhibitor 3 PubMed PubMed
CHEMBL2103840 DINACICLIB Cyclin-dependent kinase 9 inhibitor 3 PubMed
CHEMBL14762 SELICICLIB Cyclin-dependent kinase 9 inhibitor 2 PubMed PubMed PubMed
CHEMBL3545283 Riviciclib Cyclin-dependent kinase 9 inhibitor 2 PubMed PubMed
CHEMBL296468 BMS-387032 Cyclin-dependent kinase 9 inhibitor 1 PubMed PubMed
CHEMBL1944698 TG-02 Cyclin-dependent kinase 9 inhibitor 1 PubMed
CHEMBL3545083 RGB-286638 Cyclin-dependent kinase 9 inhibitor 1 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000136807
Ensembl ENSG00000136807
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0008023 (transcription elongation factor complex)
GO:0008024 (cyclin/CDK positive transcription elongation factor complex)
GO:0016020 (membrane)
GO:0016605 (PML body)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000979 (RNA polymerase II core promoter sequence-specific DNA binding)
GO:0001223 (transcription coactivator binding)
GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004693 (cyclin-dependent protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008134 (transcription factor binding)
GO:0008353 (RNA polymerase II carboxy-terminal domain kinase activity)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0017069 (snRNA binding)
GO:0044212 (transcription regulatory region DNA binding)
GO:0097322 (7SK snRNA binding)
GO Biological Process GO:0006281 (DNA repair)
GO:0006282 (regulation of DNA repair)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0006368 (transcription elongation from RNA polymerase II promoter)
GO:0006468 (protein phosphorylation)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0007346 (regulation of mitotic cell cycle)
GO:0008283 (cell proliferation)
GO:0010613 (positive regulation of cardiac muscle hypertrophy)
GO:0016310 (phosphorylation)
GO:0031056 (regulation of histone modification)
GO:0031297 (replication fork processing)
GO:0033129 (positive regulation of histone phosphorylation)
GO:0042493 (response to drug)
GO:0042795 (snRNA transcription from RNA polymerase II promoter)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0050434 (positive regulation of viral transcription)
GO:0051147 (regulation of muscle cell differentiation)
GO:0071157 (negative regulation of cell cycle arrest)
GO:0071345 (cellular response to cytokine stimulus)
GO:1900364 (negative regulation of mRNA polyadenylation)
GO:1903839 (positive regulation of mRNA 3'-UTR binding)
GO:2001168 (positive regulation of histone H2B ubiquitination)
Wikipedia Cyclin-dependent_kinase_9

Target Cross References - Protein

canSAR P50750
Human Protein Atlas ENSG00000136807
IntAct P50750
Guide to Pharmacology 1981
Open Targets ENSG00000136807
PharmGKB PA26316
Pharos P50750 (Tclin)
Reactome R-HSA-112382 (Formation of RNA Pol II elongation complex.)
R-HSA-167152 (Formation of HIV elongation complex in the absence of HIV Tat.)
R-HSA-167200 (Formation of HIV-1 elongation complex containing HIV-1 Tat.)
R-HSA-167238 (Pausing and recovery of Tat-mediated HIV elongation.)
R-HSA-167243 (Tat-mediated HIV elongation arrest and recovery.)
R-HSA-167246 (Tat-mediated elongation of the HIV-1 transcript.)
R-HSA-167287 (HIV elongation arrest and recovery.)
R-HSA-167290 (Pausing and recovery of HIV elongation.)
R-HSA-176034 (Interactions of Tat with host cellular proteins.)
R-HSA-2173796 (SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.)
R-HSA-674695 (RNA Polymerase II Pre-transcription Events.)
R-HSA-6796648 (TP53 Regulates Transcription of DNA Repair Genes.)
R-HSA-6807505 (RNA polymerase II transcribes snRNA genes.)
R-HSA-75955 (RNA Polymerase II Transcription Elongation.)
UniProt P50750 Q5JU24 Q5JU25 Q5U006 Q96TF1

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 3BLH 3BLQ 3BLR 3LQ5 3MI9 3MIA 3MY1 3TN8 3TNH 3TNI 4BCF 4BCG 4BCH 4BCI 4BCJ 4EC8 4EC9 4IMY 4OGR 4OR5
CREDO 3BLH 3BLQ 3BLR 3LQ5 3MI9 3MIA 3MY1 3TN8 3TNH 3TNI 4BCF 4BCG 4BCH 4BCI 4BCJ 4EC8 4EC9 4IMY 4OGR 4OR5
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