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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3111
Target Type SINGLE PROTEIN
Preferred Name Ribosomal protein S6 kinase 2
Synonyms 70 kDa ribosomal protein S6 kinase 2 | P70S6K2 | RPS6KB2 | Ribosomal protein S6 kinase beta-2 | S6 kinase-related kinase | S6K-beta | S6K-beta-2 | S6K2 | SRK | STK14B | Serine/threonine-protein kinase 14B | p70 S6 kinase beta | p70 S6K-beta | p70 S6KB | p70 ribosomal S6 kinase beta | p70-S6K 2 | p70-beta
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase rsk family > agc protein kinase p70 subfamily

Target Components

Component Description Relationship Accession
Ribosomal protein S6 kinase beta-2 SINGLE PROTEIN Q9UBS0

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111330 Ribosomal protein S6 kinase (P70S6K) PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000175634
Ensembl ENSG00000175634
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0004711 (ribosomal protein S6 kinase activity)
GO:0005524 (ATP binding)
GO:0004674 (protein serine/threonine kinase activity)
GO:0042277 (peptide binding)
GO:0004672 (protein kinase activity)
GO Biological Process GO:0006412 (translation)
GO:0007165 (signal transduction)
GO:0006468 (protein phosphorylation)
GO:0048011 (neurotrophin TRK receptor signaling pathway)
GO:0048015 (phosphatidylinositol-mediated signaling)
GO:0035556 (intracellular signal transduction)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0045087 (innate immune response)
GO:0008543 (fibroblast growth factor receptor signaling pathway)
GO:0007173 (epidermal growth factor receptor signaling pathway)
GO:0043491 (protein kinase B signaling)
GO:0045948 (positive regulation of translational initiation)
Wikipedia RPS6KB2

Target Cross References - Protein

Human Protein Atlas ENSG00000175634
IntAct Q9UBS0
Guide to Pharmacology 1526 (ribosomal protein S6 kinase, 70kDa, polypeptide 2)
PharmGKB PA34852
UniProt O94809 Q9UEC1 B2RMZ9 Q9UBS0

Target Cross References - Domain

InterPro IPR008271 (Ser/Thr_kinase_AS.)
IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017892 (Pkinase_C.)
IPR002290 (Ser/Thr_dual-sp_kinase.)
IPR011009 (Kinase-like_dom.)
IPR016238 (Ribosomal_S6_kinase.)
Pfam PF00433 (Pkinase_C)
PF00069 (Pkinase)
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