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Target Report Card

Target Name and Classification

Target ID CHEMBL3111
Preferred Name Ribosomal protein S6 kinase 2
Synonyms 70 kDa ribosomal protein S6 kinase 2 | P70S6K2 | RPS6KB2 | Ribosomal protein S6 kinase beta-2 | S6 kinase-related kinase | S6K-beta | S6K-beta-2 | S6K2 | SRK | STK14B | Serine/threonine-protein kinase 14B | p70 S6 kinase beta | p70 S6K-beta | p70 S6KB | p70 ribosomal S6 kinase beta | p70-S6K 2 | p70-beta
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase rsk family > agc protein kinase p70 subfamily

Target Components

Component Description Relationship Accession
Ribosomal protein S6 kinase beta-2 SINGLE PROTEIN Q9UBS0

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111330 Ribosomal protein S6 kinase (P70S6K) PROTEIN COMPLEX
CHEMBL3832633 Ribosomal protein S6 kinase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000175634
Ensembl ENSG00000175634
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004711 (ribosomal protein S6 kinase activity)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0042277 (peptide binding)
GO Biological Process GO:0006412 (translation)
GO:0006468 (protein phosphorylation)
GO:0007165 (signal transduction)
GO:0016310 (phosphorylation)
GO:0035556 (intracellular signal transduction)
GO:0043491 (protein kinase B signaling)
GO:0045948 (positive regulation of translational initiation)
Wikipedia RPS6KB2

Target Cross References - Protein

Human Protein Atlas ENSG00000175634
IntAct Q9UBS0
Guide to Pharmacology 1526
Open Targets ENSG00000175634
PharmGKB PA34852
Pharos Q9UBS0 (Tbio)
Reactome R-HSA-198693 (AKT phosphorylates targets in the nucleus.)
R-HSA-5674400 (Constitutive Signaling by AKT1 E17K in Cancer.)
UniProt B2RMZ9 B4DML8 O94809 Q9UBS0 Q9UEC1

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR016238 (Ribosomal_S6_kinase.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017892 (Pkinase_C.)
Pfam PF00069 (Pkinase)
PF00433 (Pkinase_C)