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Target Report Card

Target Name and Classification

Target ID CHEMBL3107
Target Type SINGLE PROTEIN
Preferred Name Basic fibroblast growth factor
Synonyms Basic fibroblast growth factor | FGF-2 | FGF2 | FGFB | Fibroblast growth factor 2 | HBGF-2 | Heparin-binding growth factor 2 | bFGF
Organism Homo sapiens
Species Group No
Protein Target Classification
  • secreted protein

Target Components

Component Description Relationship Accession
Fibroblast growth factor 2 SINGLE PROTEIN P09038

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1615835 MUPARFOSTAT Basic fibroblast growth factor inhibitor 3 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000138685
Ensembl ENSG00000138685
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO Molecular Function GO:0004713 (protein tyrosine kinase activity)
GO:0005088 (Ras guanyl-nucleotide exchange factor activity)
GO:0005102 (receptor binding)
GO:0005104 (fibroblast growth factor receptor binding)
GO:0005125 (cytokine activity)
GO:0005515 (protein binding)
GO:0008083 (growth factor activity)
GO:0008201 (heparin binding)
GO:0016303 (1-phosphatidylinositol-3-kinase activity)
GO:0030374 (ligand-dependent nuclear receptor transcription coactivator activity)
GO:0042056 (chemoattractant activity)
GO:0046934 (phosphatidylinositol-4,5-bisphosphate 3-kinase activity)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0000187 (activation of MAPK activity)
GO:0001525 (angiogenesis)
GO:0001658 (branching involved in ureteric bud morphogenesis)
GO:0001938 (positive regulation of endothelial cell proliferation)
GO:0002042 (cell migration involved in sprouting angiogenesis)
GO:0006661 (phosphatidylinositol biosynthetic process)
GO:0006935 (chemotaxis)
GO:0007165 (signal transduction)
GO:0007265 (Ras protein signal transduction)
GO:0007275 (multicellular organism development)
GO:0007399 (nervous system development)
GO:0008284 (positive regulation of cell proliferation)
GO:0008543 (fibroblast growth factor receptor signaling pathway)
GO:0009887 (organ morphogenesis)
GO:0010764 (negative regulation of fibroblast migration)
GO:0010863 (positive regulation of phospholipase C activity)
GO:0014066 (regulation of phosphatidylinositol 3-kinase signaling)
GO:0014843 (growth factor dependent regulation of skeletal muscle satellite cell proliferation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0030154 (cell differentiation)
GO:0030198 (extracellular matrix organization)
GO:0030214 (hyaluronan catabolic process)
GO:0032958 (inositol phosphate biosynthetic process)
GO:0035019 (somatic stem cell population maintenance)
GO:0036092 (phosphatidylinositol-3-phosphate biosynthetic process)
GO:0042060 (wound healing)
GO:0042660 (positive regulation of cell fate specification)
GO:0043406 (positive regulation of MAP kinase activity)
GO:0043536 (positive regulation of blood vessel endothelial cell migration)
GO:0043537 (negative regulation of blood vessel endothelial cell migration)
GO:0043547 (positive regulation of GTPase activity)
GO:0043552 (positive regulation of phosphatidylinositol 3-kinase activity)
GO:0045765 (regulation of angiogenesis)
GO:0045766 (positive regulation of angiogenesis)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046854 (phosphatidylinositol phosphorylation)
GO:0048015 (phosphatidylinositol-mediated signaling)
GO:0048598 (embryonic morphogenesis)
GO:0050918 (positive chemotaxis)
GO:0051209 (release of sequestered calcium ion into cytosol)
GO:0051781 (positive regulation of cell division)
GO:0060045 (positive regulation of cardiac muscle cell proliferation)
GO:0060548 (negative regulation of cell death)
GO:0060591 (chondroblast differentiation)
GO:0061045 (negative regulation of wound healing)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:1903672 (positive regulation of sprouting angiogenesis)
GO:2000544 (regulation of endothelial cell chemotaxis to fibroblast growth factor)
GO:2000546 (positive regulation of endothelial cell chemotaxis to fibroblast growth factor)
Wikipedia Basic_fibroblast_growth_factor

Target Cross References - Protein

canSAR P09038
Human Protein Atlas ENSG00000138685
IntAct P09038
Open Targets ENSG00000138685
PharmGKB PA28115
Reactome R-HSA-109704 (PI3K Cascade.)
R-HSA-1257604 (PIP3 activates AKT signaling.)
R-HSA-1839122 (Signaling by activated point mutants of FGFR1.)
R-HSA-1839130 (Signaling by activated point mutants of FGFR3.)
R-HSA-190322 (FGFR4 ligand binding and activation.)
R-HSA-190370 (FGFR1b ligand binding and activation.)
R-HSA-190372 (FGFR3c ligand binding and activation.)
R-HSA-190373 (FGFR1c ligand binding and activation.)
R-HSA-190375 (FGFR2c ligand binding and activation.)
R-HSA-190377 (FGFR2b ligand binding and activation.)
R-HSA-2033514 (FGFR3 mutant receptor activation.)
R-HSA-2033519 (Activated point mutants of FGFR2.)
R-HSA-2219530 (Constitutive Signaling by Aberrant PI3K in Cancer.)
R-HSA-2892247 (POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.)
R-HSA-3000170 (Syndecan interactions.)
R-HSA-3000171 (Non-integrin membrane-ECM interactions.)
R-HSA-5654219 (Phospholipase C-mediated cascade: FGFR1.)
R-HSA-5654221 (Phospholipase C-mediated cascade, FGFR2.)
R-HSA-5654227 (Phospholipase C-mediated cascade, FGFR3.)
R-HSA-5654228 (Phospholipase C-mediated cascade, FGFR4.)
R-HSA-5654687 (Downstream signaling of activated FGFR1.)
R-HSA-5654688 (SHC-mediated cascade:FGFR1.)
R-HSA-5654689 (PI-3K cascade:FGFR1.)
R-HSA-5654693 (FRS-mediated FGFR1 signaling.)
R-HSA-5654695 (PI-3K cascade:FGFR2.)
R-HSA-5654699 (SHC-mediated cascade:FGFR2.)
R-HSA-5654700 (FRS-mediated FGFR2 signaling.)
R-HSA-5654704 (SHC-mediated cascade:FGFR3.)
R-HSA-5654706 (FRS-mediated FGFR3 signaling.)
R-HSA-5654710 (PI-3K cascade:FGFR3.)
R-HSA-5654712 (FRS-mediated FGFR4 signaling.)
R-HSA-5654719 (SHC-mediated cascade:FGFR4.)
R-HSA-5654720 (PI-3K cascade:FGFR4.)
R-HSA-5654726 (Negative regulation of FGFR1 signaling.)
R-HSA-5654727 (Negative regulation of FGFR2 signaling.)
R-HSA-5654732 (Negative regulation of FGFR3 signaling.)
R-HSA-5654733 (Negative regulation of FGFR4 signaling.)
R-HSA-5655253 (Signaling by FGFR2 in disease.)
R-HSA-5655302 (Signaling by FGFR1 in disease.)
R-HSA-5658623 (FGFRL1 modulation of FGFR1 signaling.)
R-HSA-5673001 (RAF/MAP kinase cascade.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
R-HSA-6811558 (PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.)
R-HSA-8851708 (Signaling by FGFR2 IIIa TM.)
R-HSA-8853338 (Signaling by FGFR3 point mutants in cancer.)
UniProt A4LBB8 O00527 P09038 P78443 Q16443 Q5PY50 Q7KZ11 Q7KZ72 Q9UC54 Q9UCS5 Q9UCS6

Target Cross References - Domain

InterPro IPR002209 (Fibroblast_GF_fam.)
IPR008996 (IL1/FGF.)
IPR028223 (FGF2.)
Pfam PF00167 (FGF)

Target Cross References - Structure

PDBe 1BAS 1BFB 1BFC 1BFF 1BFG 1CVS 1EV2 1FGA 1FQ9 1II4 1IIL 2BFH 2FGF 4FGF 4OEE 4OEF 4OEG
CREDO 1BAS 1BFB 1BFC 1BFF 1BFG 1CVS 1EV2 1FGA 1FQ9 1II4 1IIL 2BFH 2FGF 4FGF 4OEE 4OEF 4OEG
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