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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3106
Target Type SINGLE PROTEIN
Preferred Name Thymidine phosphorylase
Synonyms ECGF1 | Gliostatin | PD-ECGF | Platelet-derived endothelial cell growth factor | TP | TYMP | TdRPase | Thymidine phosphorylase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Thymidine phosphorylase SINGLE PROTEIN P19971

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL65375 TIPIRACIL HYDROCHLORIDE Thymidine phosphorylase inhibitor 4 DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000025708
Ensembl ENSG00000025708
GO Cellular Component GO:0005829 (cytosol)
GO Molecular Function GO:0004645 (phosphorylase activity)
GO:0005161 (platelet-derived growth factor receptor binding)
GO:0008083 (growth factor activity)
GO:0009032 (thymidine phosphorylase activity)
GO:0016154 (pyrimidine-nucleoside phosphorylase activity)
GO:0016740 (transferase activity)
GO:0016757 (transferase activity, transferring glycosyl groups)
GO:0016763 (transferase activity, transferring pentosyl groups)
GO Biological Process GO:0000002 (mitochondrial genome maintenance)
GO:0001525 (angiogenesis)
GO:0006206 (pyrimidine nucleobase metabolic process)
GO:0006213 (pyrimidine nucleoside metabolic process)
GO:0006220 (pyrimidine nucleotide metabolic process)
GO:0006260 (DNA replication)
GO:0006935 (chemotaxis)
GO:0007275 (multicellular organism development)
GO:0008152 (metabolic process)
GO:0030154 (cell differentiation)
GO:0043097 (pyrimidine nucleoside salvage)
GO:0046135 (pyrimidine nucleoside catabolic process)
Wikipedia ECGF1

Target Cross References - Protein

canSAR P19971
CGD Mitochondrial DNA depletion syndrome 1 (MNGIE type)
Human Protein Atlas ENSG00000025708
IntAct P19971
Open Targets ENSG00000025708
PharmGKB PA162407502
Reactome R-HSA-73614 (Pyrimidine salvage reactions.)
R-HSA-73621 (Pyrimidine catabolism.)
UniProt A8MW15 H9KVA0 P19971 Q13390 Q8WVB7

Target Cross References - Domain

InterPro IPR000053 (Thymidine/pyrmidine_PPase.)
IPR000312 (Glycosyl_Trfase_fam3.)
IPR013102 (PYNP_C.)
IPR017459 (Glycosyl_Trfase_fam3_N_dom.)
IPR017872 (Pyrmidine_PPase_CS.)
IPR018090 (Pyrmidine_PPas_bac/euk.)
Pfam PF00591 (Glycos_transf_3)
PF02885 (Glycos_trans_3N)
PF07831 (PYNP_C)

Target Cross References - Structure

PDBe 1UOU 2J0F 2WK5 2WK6
CREDO 1UOU 2J0F 2WK5 2WK6
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