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Target Report Card

Target Name and Classification

Target ID CHEMBL3102
Target Type SINGLE PROTEIN
Preferred Name Dopamine beta-hydroxylase
Synonyms DBH | Dopamine beta-hydroxylase | Dopamine beta-monooxygenase | Soluble dopamine beta-hydroxylase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Dopamine beta-hydroxylase SINGLE PROTEIN P09172

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000123454
Ensembl ENSG00000123454
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016023 (cytoplasmic, membrane-bounded vesicle)
GO:0030658 (transport vesicle membrane)
GO:0030667 (secretory granule membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0034466 (chromaffin granule lumen)
GO:0034774 (secretory granule lumen)
GO:0042584 (chromaffin granule membrane)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004497 (monooxygenase activity)
GO:0004500 (dopamine beta-monooxygenase activity)
GO:0005507 (copper ion binding)
GO:0016491 (oxidoreductase activity)
GO:0016715 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen)
GO:0031418 (L-ascorbic acid binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001816 (cytokine production)
GO:0001974 (blood vessel remodeling)
GO:0001975 (response to amphetamine)
GO:0002443 (leukocyte mediated immunity)
GO:0007268 (chemical synaptic transmission)
GO:0007613 (memory)
GO:0007626 (locomotory behavior)
GO:0008306 (associative learning)
GO:0008542 (visual learning)
GO:0042127 (regulation of cell proliferation)
GO:0042309 (homoiothermy)
GO:0042420 (dopamine catabolic process)
GO:0042421 (norepinephrine biosynthetic process)
GO:0042423 (catecholamine biosynthetic process)
GO:0042593 (glucose homeostasis)
GO:0042596 (fear response)
GO:0042711 (maternal behavior)
GO:0045907 (positive regulation of vasoconstriction)
GO:0048149 (behavioral response to ethanol)
GO:0048265 (response to pain)
GO:0050900 (leukocyte migration)
GO:0055114 (oxidation-reduction process)
GO:2001236 (regulation of extrinsic apoptotic signaling pathway)
Wikipedia Dopamine_beta_hydroxylase

Target Cross References - Protein

canSAR P09172
CGD Dopamine beta-hydroxylase deficiency
Human Protein Atlas ENSG00000123454
IntAct P09172
Guide to Pharmacology 2486
Open Targets ENSG00000123454
PharmGKB PA136
Reactome R-HSA-209905 (Catecholamine biosynthesis.)
UniProt P09172 Q5T381 Q96AG2

Target Cross References - Domain

InterPro IPR000323 (Cu2_ascorb_mOase_N.)
IPR000945 (DBH-rel.)
IPR005018 (DOMON_domain.)
IPR008977 (PHM/PNGase_F_dom.)
IPR014783 (Cu2_ascorb_mOase_CS-2.)
IPR014784 (Cu2_ascorb_mOase-like_C.)
IPR020611 (Cu2_ascorb_mOase_CS-1.)
IPR024548 (Cu2_monoox_C.)
IPR028460 (Tbh/DBH.)
Pfam PF01082 (Cu2_monooxygen)
PF03351 (DOMON)
PF03712 (Cu2_monoox_C)

Target Cross References - Structure

PDBe 4ZEL
CREDO 4ZEL
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