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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3102
Target Type SINGLE PROTEIN
Preferred Name Dopamine beta-hydroxylase
Synonyms DBH | Dopamine beta-hydroxylase | Dopamine beta-monooxygenase | Soluble dopamine beta-hydroxylase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Dopamine beta-hydroxylase SINGLE PROTEIN P09172

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000123454
Ensembl ENSG00000123454
GO Cellular Component GO:0005576 (extracellular region)
GO:0005624 (membrane fraction)
GO:0005625 (soluble fraction)
GO:0016021 (integral to membrane)
GO:0030658 (transport vesicle membrane)
GO:0034466 (chromaffin granule lumen)
GO:0042584 (chromaffin granule membrane)
GO Molecular Function GO:0004500 (dopamine beta-monooxygenase activity)
GO:0031418 (L-ascorbic acid binding)
GO Biological Process GO:0042446 (hormone biosynthetic process)
Wikipedia Dopamine_beta_hydroxylase

Target Cross References - Protein

canSAR P09172
CGD Dopamine beta-hydroxylase deficiency
Human Protein Atlas ENSG00000123454
Guide to Pharmacology 2486 (Dopamine beta-hydroxylase (dopamine beta-monooxygenase))
PharmGKB PA136
Reactome REACT_13 (Metabolism of amino acids and derivatives.)
REACT_15314 (Hormone biosynthesis.)
UniProt P09172 Q5T381 Q96AG2

Target Cross References - Domain

InterPro IPR000323 (Cu2_ascorb_mOase_N.)
IPR000945 (Dopamine_b_mOase.)
IPR005018 (DOMON_domain.)
IPR008977 (PHM_PNGase_F-fold_dom.)
IPR014783 (Cu2_ascorb_mOase_CS-2.)
IPR014784 (Cu2_ascorb_mOase-like_C.)
IPR020611 (Cu2_ascorb_mOase_CS-1.)
Pfam PF01082 (Cu2_monooxygen)
PF03351 (DOMON)
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