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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3094
Target Type SINGLE PROTEIN
Preferred Name MAP kinase-activated protein kinase 5
Synonyms MAP kinase-activated protein kinase 5 | MAPK-activated protein kinase 5 | MAPKAP kinase 5 | MAPKAP-K5 | MAPKAPK-5 | MAPKAPK5 | MK-5 | MK5 | PRAK | PRAK | p38-regulated/activated protein kinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase mapkapk family > camk protein kinase mapkapk subfamily

Target Components

Component Description Relationship Accession
MAP kinase-activated protein kinase 5 SINGLE PROTEIN Q8IW41

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3545338 GLPG-0259 MAP kinase-activated protein kinase 5 inhibitor 2 Other PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000089022
Ensembl ENSG00000089022
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0002039 (p53 binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004683 (calmodulin-dependent protein kinase activity)
GO:0004708 (MAP kinase kinase activity)
GO:0005515 (protein binding)
GO:0005516 (calmodulin binding)
GO:0005524 (ATP binding)
GO:0009931 (calcium-dependent protein serine/threonine kinase activity)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0000187 (activation of MAPK activity)
GO:0006417 (regulation of translation)
GO:0006468 (protein phosphorylation)
GO:0007165 (signal transduction)
GO:0007265 (Ras protein signal transduction)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0032007 (negative regulation of TOR signaling)
GO:0032212 (positive regulation of telomere maintenance via telomerase)
GO:0046777 (protein autophosphorylation)
GO:0051973 (positive regulation of telomerase activity)
GO:0090400 (stress-induced premature senescence)
GO:1901796 (regulation of signal transduction by p53 class mediator)
GO:1904355 (positive regulation of telomere capping)
Wikipedia MAPKAPK5

Target Cross References - Protein

canSAR Q8IW41
Human Protein Atlas ENSG00000089022
IntAct Q8IW41
Guide to Pharmacology 2096
Open Targets ENSG00000089022
PharmGKB PA30633
Pharos Q8IW41 (Tchem)
Reactome R-HSA-2559580 (Oxidative Stress Induced Senescence.)
R-HSA-5687128 (MAPK6/MAPK4 signaling.)
R-HSA-6804756 (Regulation of TP53 Activity through Phosphorylation.)
UniProt B3KVA5 O60491 Q86X46 Q8IW41 Q9BVX9 Q9UG86

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR027442 (MAPKAPK_C.)
Pfam PF00069 (Pkinase)
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