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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3094
Preferred Name MAP kinase-activated protein kinase 5
Synonyms MAP kinase-activated protein kinase 5 | MAPK-activated protein kinase 5 | MAPKAP kinase 5 | MAPKAP-K5 | MAPKAPK-5 | MAPKAPK5 | MK-5 | MK5 | PRAK | PRAK | p38-regulated/activated protein kinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase mapkapk family > camk protein kinase mapkapk subfamily

Target Components

Component Description Relationship Accession
MAP kinase-activated protein kinase 5 SINGLE PROTEIN Q8IW41

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3545338 GLPG-0259 MAP kinase-activated protein kinase 5 inhibitor 2 Other PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000089022
Ensembl ENSG00000089022
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0004674 (protein serine/threonine kinase activity)
GO:0004708 (MAP kinase kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007165 (signal transduction)
Wikipedia MAPKAPK5

Target Cross References - Protein

canSAR Q8IW41
Human Protein Atlas ENSG00000089022
IntAct Q8IW41
Guide to Pharmacology 2096 (mitogen-activated protein kinase-activated protein kinase 5)
PharmGKB PA30633
UniProt B3KVA5 O60491 Q86X46 Q8IW41 Q9BVX9 Q9UG86

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR002290 (Ser/Thr_prot_kinase_dom.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
Pfam PF00069 (Pkinase)