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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3092
Target Type SINGLE PROTEIN
Preferred Name Cathepsin E
Synonyms CTSE | Cathepsin E form I | Cathepsin E form II | Cathepsin E
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > aspartic protease > aspartic protease aa clan > aspartic protease a1a subfamily

Target Components

Component Description Relationship Accession
Cathepsin E SINGLE PROTEIN P14091

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000196188
Ensembl ENSG00000196188
GO Cellular Component GO:0005768 (endosome)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004190 (aspartic-type endopeptidase activity)
GO:0008233 (peptidase activity)
GO:0016787 (hydrolase activity)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0006508 (proteolysis)
GO:0007586 (digestion)
GO:0016540 (protein autoprocessing)
GO:0019886 (antigen processing and presentation of exogenous peptide antigen via MHC class II)
GO:0030163 (protein catabolic process)
Wikipedia Cathepsin_E

Target Cross References - Protein

canSAR P14091
Human Protein Atlas ENSG00000196188
IntAct P14091
Guide to Pharmacology 2346
Open Targets ENSG00000196188
PharmGKB PA27030
Reactome R-HSA-2132295 (MHC class II antigen presentation.)
UniProt P14091 Q5TZ01 Q5TZ02 Q9NY58 Q9UCE3 Q9UCE4

Target Cross References - Domain

InterPro IPR001461 (Aspartic_peptidase_A1.)
IPR001969 (Aspartic_peptidase_AS.)
IPR012848 (Aspartic_peptidase_N.)
IPR021109 (Peptidase_aspartic_dom.)
IPR033121 (PEPTIDASE_A1.)
IPR033145 (Cathepsin_E.)
Pfam PF00026 (Asp)
PF07966 (A1_Propeptide)

Target Cross References - Structure

PDBe 1TZS
CREDO 1TZS
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