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Target Report Card

Target Name and Classification

Target ID CHEMBL3091
Target Type SINGLE PROTEIN
Preferred Name Neurotensin receptor 3
Synonyms 100 kDa NT receptor | Glycoprotein 95 | Gp95 | NT3 | NTR3 | Neurotensin receptor 3 | SORT1 | Sortilin
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Sortilin SINGLE PROTEIN Q99523

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000134243
Ensembl ENSG00000134243
GO Cellular Component GO:0005634 (nucleus)
GO:0005764 (lysosome)
GO:0005765 (lysosomal membrane)
GO:0005768 (endosome)
GO:0005769 (early endosome)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005905 (clathrin-coated pit)
GO:0009986 (cell surface)
GO:0010008 (endosome membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016023 (cytoplasmic, membrane-bounded vesicle)
GO:0030136 (clathrin-coated vesicle)
GO:0030140 (trans-Golgi network transport vesicle)
GO:0030425 (dendrite)
GO:0031965 (nuclear membrane)
GO:0032580 (Golgi cisterna membrane)
GO:0043025 (neuronal cell body)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0005515 (protein binding)
GO:0010465 (nerve growth factor receptor activity)
GO:0019899 (enzyme binding)
GO:0030379 (neurotensin receptor activity, non-G-protein coupled)
GO:0048406 (nerve growth factor binding)
GO Biological Process GO:0001503 (ossification)
GO:0006810 (transport)
GO:0006895 (Golgi to endosome transport)
GO:0006897 (endocytosis)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007218 (neuropeptide signaling pathway)
GO:0007275 (multicellular organism development)
GO:0008333 (endosome to lysosome transport)
GO:0008625 (extrinsic apoptotic signaling pathway via death domain receptors)
GO:0010468 (regulation of gene expression)
GO:0014902 (myotube differentiation)
GO:0016050 (vesicle organization)
GO:0030154 (cell differentiation)
GO:0032509 (endosome transport via multivesicular body sorting pathway)
GO:0032868 (response to insulin)
GO:0038180 (nerve growth factor signaling pathway)
GO:0045599 (negative regulation of fat cell differentiation)
GO:0046323 (glucose import)
GO:0048011 (neurotrophin TRK receptor signaling pathway)
GO:0048227 (plasma membrane to endosome transport)
GO:0051005 (negative regulation of lipoprotein lipase activity)
GO:1904037 (positive regulation of epithelial cell apoptotic process)
Wikipedia Sortilin_1

Target Cross References - Protein

canSAR Q99523
Human Protein Atlas ENSG00000134243
IntAct Q99523
Open Targets ENSG00000134243
PharmGKB PA36023
Reactome R-HSA-432722 (Golgi Associated Vesicle Biogenesis.)
UniProt B4DWI3 C0JYZ0 Q8IZ49 Q99523

Target Cross References - Domain

InterPro IPR006581 (VPS10.)
IPR015943 (WD40/YVTN_repeat-like_dom.)
IPR031777 (Sortilin_C.)
IPR031778 (Sortilin_N.)
Pfam PF15901 (Sortilin_C)
PF15902 (Sortilin-Vps10)

Target Cross References - Structure

PDBe 3F6K 3G2U 3G2V 4MSL 4N7E 4PO7
CREDO 3F6K 3G2U 3G2V 4MSL 4N7E 4PO7
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