ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL3088
Preferred Name Insulin-like growth factor binding protein 2
Synonyms BP2 | IBP-2 | IBP2 | IGF-binding protein 2 | IGFBP-2 | IGFBP2 | Insulin-like growth factor-binding protein 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • secreted protein

Target Components

Component Description Relationship Accession
Insulin-like growth factor-binding protein 2 SINGLE PROTEIN P18065

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000115457
Ensembl ENSG00000115457
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0016324 (apical plasma membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0005520 (insulin-like growth factor binding)
GO:0019838 (growth factor binding)
GO:0031994 (insulin-like growth factor I binding)
GO:0031995 (insulin-like growth factor II binding)
GO Biological Process GO:0001558 (regulation of cell growth)
GO:0007165 (signal transduction)
GO:0007565 (female pregnancy)
GO:0007568 (aging)
GO:0007584 (response to nutrient)
GO:0009612 (response to mechanical stimulus)
GO:0010226 (response to lithium ion)
GO:0032355 (response to estradiol)
GO:0032526 (response to retinoic acid)
GO:0032870 (cellular response to hormone stimulus)
GO:0040008 (regulation of growth)
GO:0042104 (positive regulation of activated T cell proliferation)
GO:0042493 (response to drug)
GO:0043567 (regulation of insulin-like growth factor receptor signaling pathway)
GO:0043627 (response to estrogen)
GO:0044267 (cellular protein metabolic process)
GO:0048545 (response to steroid hormone)
GO:0051384 (response to glucocorticoid)
GO:0090090 (negative regulation of canonical Wnt signaling pathway)
Wikipedia IGFBP2

Target Cross References - Protein

canSAR P18065
Human Protein Atlas ENSG00000115457
IntAct P18065
Open Targets ENSG00000115457
PharmGKB PA29704
Reactome R-HSA-381426 (Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).)
UniProt P18065 Q14619 Q9UCL3

Target Cross References - Domain

InterPro IPR000716 (Thyroglobulin_1.)
IPR000867 (IGFBP-like.)
IPR009030 (Growth_fac_rcpt_.)
IPR009168 (IGFBP1-6.)
IPR012210 (IGFBP-2.)
IPR017891 (Insulin_GF-bd_Cys-rich_CS.)
IPR022321 (IGFBP_1-6_chordata.)
Pfam PF00086 (Thyroglobulin_1)
PF00219 (IGFBP)