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Target Report Card

Target Name and Classification

Target ID CHEMBL3085
Preferred Name Excitatory amino acid transporter 1
Synonyms EAAT1 | Excitatory amino acid transporter 1 | GLAST | GLAST-1 | GLAST1 | SLC1A3 | Sodium-dependent glutamate/aspartate transporter 1 | Solute carrier family 1 member 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc01 family of amino acid transporters

Target Components

Component Description Relationship Accession
Excitatory amino acid transporter 1 SINGLE PROTEIN P43003

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000079215
Ensembl ENSG00000079215
GO Cellular Component GO:0005624 (membrane fraction)
GO:0016021 (integral to membrane)
GO Molecular Function GO:0005314 (high-affinity glutamate transmembrane transporter activity)
GO:0017153 (sodium:dicarboxylate symporter activity)
GO Biological Process GO:0001504 (neurotransmitter uptake)
GO:0051938 (L-glutamate import)
GO:0070779 (D-aspartate import)
Wikipedia Glutamate_aspartate_transporter

Target Cross References - Protein

canSAR P43003
CGD Episodic ataxia, type 6
Human Protein Atlas ENSG00000079215
IntAct P43003
Guide to Pharmacology 868 (Excitatory amino acid transporter 1)
PharmGKB PA35828
Reactome REACT_13685 (Synaptic Transmission.)
REACT_15518 (Transmembrane transport of small molecules.)
REACT_19419 (Amino acid and oligopeptide SLC transporters.)
UniProt B2R5T3 P43003

Target Cross References - Domain

InterPro IPR001991 (Na-dicarboxylate_symporter.)
IPR018107 (Na-dicarboxylate_symporter_CS.)
Pfam PF00375 (SDF)