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Target Report Card

Target Name and Classification

Target ID CHEMBL3085
Preferred Name Excitatory amino acid transporter 1
Synonyms EAAT1 | Excitatory amino acid transporter 1 | GLAST | GLAST-1 | GLAST1 | SLC1A3 | Sodium-dependent glutamate/aspartate transporter 1 | Solute carrier family 1 member 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc01 family of amino acid transporters

Target Components

Component Description Relationship Accession
Excitatory amino acid transporter 1 SINGLE PROTEIN P43003

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000079215
Ensembl ENSG00000079215
GO Cellular Component GO:0005743 (mitochondrial inner membrane)
GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0042995 (cell projection)
GO:0043005 (neuron projection)
GO:0043025 (neuronal cell body)
GO:0043197 (dendritic spine)
GO:0043205 (fibril)
GO:0045202 (synapse)
GO:0071944 (cell periphery)
GO Molecular Function GO:0005313 (L-glutamate transmembrane transporter activity)
GO:0005314 (high-affinity glutamate transmembrane transporter activity)
GO:0015171 (amino acid transmembrane transporter activity)
GO:0015293 (symporter activity)
GO:0016595 (glutamate binding)
GO:0016597 (amino acid binding)
GO Biological Process GO:0001504 (neurotransmitter uptake)
GO:0002230 (positive regulation of defense response to virus by host)
GO:0003333 (amino acid transmembrane transport)
GO:0006536 (glutamate metabolic process)
GO:0006537 (glutamate biosynthetic process)
GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0007268 (chemical synaptic transmission)
GO:0007605 (sensory perception of sound)
GO:0009416 (response to light stimulus)
GO:0009449 (gamma-aminobutyric acid biosynthetic process)
GO:0009611 (response to wounding)
GO:0014047 (glutamate secretion)
GO:0015813 (L-glutamate transport)
GO:0021545 (cranial nerve development)
GO:0031223 (auditory behavior)
GO:0042493 (response to drug)
GO:0043490 (malate-aspartate shuttle)
GO:0046677 (response to antibiotic)
GO:0048667 (cell morphogenesis involved in neuron differentiation)
GO:0050806 (positive regulation of synaptic transmission)
GO:0050885 (neuromuscular process controlling balance)
GO:0051938 (L-glutamate import)
GO:0055085 (transmembrane transport)
GO:0070779 (D-aspartate import)
GO:0089711 (L-glutamate transmembrane transport)
GO:0098779 (mitophagy in response to mitochondrial depolarization)
GO:0098792 (xenophagy)
Wikipedia Glutamate_aspartate_transporter

Target Cross References - Protein

canSAR P43003
CGD Episodic ataxia, type 6
Human Protein Atlas ENSG00000079215
IntAct P43003
Guide to Pharmacology 868
Open Targets ENSG00000079215
PharmGKB PA35828
Reactome R-HSA-210455 (Astrocytic Glutamate-Glutamine Uptake And Metabolism.)
R-HSA-210500 (Glutamate Neurotransmitter Release Cycle.)
R-HSA-425393 (Transport of inorganic cations/anions and amino acids/oligopeptides.)
UniProt B2R5T3 P43003 Q4JCQ8

Target Cross References - Domain

InterPro IPR001991 (Na-dicarboxylate_symporter.)
IPR018107 (Na-dicarboxylate_symporter_CS.)
Pfam PF00375 (SDF)