ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL3079
Preferred Name Thiamine transporter 1
Synonyms SLC19A2 | Solute carrier family 19 member 2 | TC1 | THT1 | TRMA | ThTr-1 | ThTr1 | Thiamine carrier 1 | Thiamine transporter 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc19 family of vitamin transporters

Target Components

Component Description Relationship Accession
Thiamine transporter 1 SINGLE PROTEIN O60779

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000117479
Ensembl ENSG00000117479
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0005515 (protein binding)
GO:0008517 (folic acid transporter activity)
GO:0015234 (thiamine transmembrane transporter activity)
GO:0015403 (thiamine uptake transmembrane transporter activity)
GO Biological Process GO:0006810 (transport)
GO:0015884 (folic acid transport)
GO:0015888 (thiamine transport)
GO:0042723 (thiamine-containing compound metabolic process)
GO:0071934 (thiamine transmembrane transport)
Wikipedia SLC19A2

Target Cross References - Protein

canSAR O60779
CGD Thiamine-responsive megaloblastic anemia syndrome
Human Protein Atlas ENSG00000117479
IntAct O60779
Open Targets ENSG00000117479
PharmGKB PA35825
Reactome R-HSA-196819 (Vitamin B1 (thiamin) metabolism.)
UniProt B2R9H0 B4E1X4 O60779 Q8WV87 Q9UBL7 Q9UKJ2 Q9UN31 Q9UN43

Target Cross References - Domain

InterPro IPR002666 (Folate_carrier.)
IPR020846 (MFS_dom.)
IPR028338 (ThTr-1.)
Pfam PF01770 (Folate_carrier)