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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3076
Target Type SINGLE PROTEIN
Preferred Name Phenylalanine-4-hydroxylase
Synonyms PAH | PAH | Phe-4-monooxygenase | Phenylalanine-4-hydroxylase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
Phenylalanine-4-hydroxylase SINGLE PROTEIN P00439

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1201775 SAPROPTERIN DIHYDROCHLORIDE Phenylalanine-4-hydroxylase activator 4 DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000171759
Ensembl ENSG00000171759
GO Cellular Component GO:0005829 (cytosol)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004497 (monooxygenase activity)
GO:0004505 (phenylalanine 4-monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0016491 (oxidoreductase activity)
GO:0016714 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006559 (L-phenylalanine catabolic process)
GO:0008152 (metabolic process)
GO:0008652 (cellular amino acid biosynthetic process)
GO:0009072 (aromatic amino acid family metabolic process)
GO:0042136 (neurotransmitter biosynthetic process)
GO:0042423 (catecholamine biosynthetic process)
GO:0055114 (oxidation-reduction process)
Wikipedia Phenylalanine_hydroxylase

Target Cross References - Protein

canSAR P00439
CGD Phenylketonuria; Hyperphenylalaninemia, non-PKU mild
Human Protein Atlas ENSG00000171759
IntAct P00439
Guide to Pharmacology 1240
Open Targets ENSG00000171759
PharmGKB PA32911
Reactome R-HSA-2160456 (Phenylketonuria.)
R-HSA-71182 (Phenylalanine and tyrosine catabolism.)
UniProt P00439 Q16717 Q8TC14

Target Cross References - Domain

InterPro IPR001273 (ArAA_hydroxylase.)
IPR002912 (ACT_dom.)
IPR005961 (Phe-4-hydroxylase_tetra.)
IPR018301 (ArAA_hydroxylase_Fe/CU_BS.)
IPR019773 (Tyrosine_3-monooxygenase-like.)
IPR019774 (Aromatic-AA_hydroxylase_C.)
IPR036329 (Aro-AA_hydroxylase_C_sf.)
IPR036951 (ArAA_hydroxylase_sf.)
Pfam PF00351 (Biopterin_H)
PF01842 (ACT)

Target Cross References - Structure

PDBe 1DMW 1J8T 1J8U 1KW0 1LRM 1MMK 1MMT 1PAH 1TDW 1TG2 2PAH 3PAH 4ANP 4PAH 5FII 5PAH 6PAH
CREDO 1DMW 1J8T 1J8U 1KW0 1LRM 1MMK 1MMT 1PAH 1TDW 1TG2 2PAH 3PAH 4ANP 4PAH 5FII 5PAH 6PAH
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