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Target Report Card

Target Name and Classification

Target ID CHEMBL3070
Preferred Name Intercellular adhesion molecule-1
Synonyms CD_antigen=CD54 | ICAM-1 | ICAM1 | Intercellular adhesion molecule 1 | Major group rhinovirus receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • adhesion

Target Components

Component Description Relationship Accession
Intercellular adhesion molecule 1 SINGLE PROTEIN P05362

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096661 Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2 PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2108401 ENLIMOMAB PEGOL Intercellular adhesion molecule-1 antagonist 2 PubMed
CHEMBL2109482 BI-505 Intercellular adhesion molecule-1 antagonist 2 PubMed
CHEMBL2109090 ENLIMOMAB Intercellular adhesion molecule-1 inhibitor 0 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000090339
Ensembl ENSG00000090339
GO Cellular Component GO:0001772 (immunological synapse)
GO:0005615 (extracellular space)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005925 (focal adhesion)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031012 (extracellular matrix)
GO:0045121 (membrane raft)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0001618 (virus receptor activity)
GO:0004888 (transmembrane signaling receptor activity)
GO:0005178 (integrin binding)
GO:0005515 (protein binding)
GO:0038023 (signaling receptor activity)
GO:0044877 (macromolecular complex binding)
GO Biological Process GO:0001541 (ovarian follicle development)
GO:0001666 (response to hypoxia)
GO:0001910 (regulation of leukocyte mediated cytotoxicity)
GO:0001975 (response to amphetamine)
GO:0002291 (T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)
GO:0002438 (acute inflammatory response to antigenic stimulus)
GO:0002457 (T cell antigen processing and presentation)
GO:0002693 (positive regulation of cellular extravasation)
GO:0007155 (cell adhesion)
GO:0007157 (heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)
GO:0007159 (leukocyte cell-cell adhesion)
GO:0007569 (cell aging)
GO:0007605 (sensory perception of sound)
GO:0008360 (regulation of cell shape)
GO:0010212 (response to ionizing radiation)
GO:0010477 (response to sulfur dioxide)
GO:0014070 (response to organic cyclic compound)
GO:0016032 (viral process)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0022614 (membrane to membrane docking)
GO:0030155 (regulation of cell adhesion)
GO:0030198 (extracellular matrix organization)
GO:0030838 (positive regulation of actin filament polymerization)
GO:0031669 (cellular response to nutrient levels)
GO:0032496 (response to lipopolysaccharide)
GO:0032868 (response to insulin)
GO:0033627 (cell adhesion mediated by integrin)
GO:0034698 (response to gonadotropin)
GO:0042493 (response to drug)
GO:0043200 (response to amino acid)
GO:0043547 (positive regulation of GTPase activity)
GO:0044406 (adhesion of symbiont to host)
GO:0045429 (positive regulation of nitric oxide biosynthetic process)
GO:0045471 (response to ethanol)
GO:0045907 (positive regulation of vasoconstriction)
GO:0046688 (response to copper ion)
GO:0046718 (viral entry into host cell)
GO:0046813 (receptor-mediated virion attachment to host cell)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0050776 (regulation of immune response)
GO:0050900 (leukocyte migration)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051926 (negative regulation of calcium ion transport)
GO:0060333 (interferon-gamma-mediated signaling pathway)
GO:0061028 (establishment of endothelial barrier)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0071310 (cellular response to organic substance)
GO:0071312 (cellular response to alkaloid)
GO:0071333 (cellular response to glucose stimulus)
GO:0071346 (cellular response to interferon-gamma)
GO:0071347 (cellular response to interleukin-1)
GO:0071354 (cellular response to interleukin-6)
GO:0071356 (cellular response to tumor necrosis factor)
GO:0071456 (cellular response to hypoxia)
GO:0071549 (cellular response to dexamethasone stimulus)
GO:0072683 (T cell extravasation)
GO:0090557 (establishment of endothelial intestinal barrier)
GO:0097368 (establishment of Sertoli cell barrier)
GO:0098609 (cell-cell adhesion)
GO:1900027 (regulation of ruffle assembly)
GO:1902042 (negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)
GO:1904996 (positive regulation of leukocyte adhesion to vascular endothelial cell)
GO:1990830 (cellular response to leukemia inhibitory factor)
GO:2000352 (negative regulation of endothelial cell apoptotic process)
Wikipedia ICAM-1

Target Cross References - Protein

canSAR P05362
Human Protein Atlas ENSG00000090339
IntAct P05362
Open Targets ENSG00000090339
PharmGKB PA29592
Reactome R-HSA-198933 (Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.)
R-HSA-216083 (Integrin cell surface interactions.)
R-HSA-6783783 (Interleukin-10 signaling.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
R-HSA-877300 (Interferon gamma signaling.)
UniProt B2R6M3 P05362 Q5NKV7 Q96B50

Target Cross References - Domain

InterPro IPR003599 (Ig_sub.)
IPR003987 (ICAM_VCAM_N.)
IPR003988 (ICAM.)
IPR013768 (ICAM_N.)
IPR013783 (Ig-like_fold.)
IPR036179 (Ig-like_dom_sf.)
Pfam PF03921 (ICAM_N)

Target Cross References - Structure

PDBe 1D3L 1IAM 1IC1 1MQ8 1P53 2OZ4 3TCX 5MZA