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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3060
Preferred Name Glycine transporter 2
Synonyms GLYT2 | GlyT-2 | GlyT2 | NET1 | SLC6A5 | Sodium- and chloride-dependent glycine transporter 2 | Solute carrier family 6 member 5
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc06 neurotransmitter transporter family

Target Components

Component Description Relationship Accession
Sodium- and chloride-dependent glycine transporter 2 SINGLE PROTEIN Q9Y345

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000165970
Ensembl ENSG00000165970
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0005328 (neurotransmitter:sodium symporter activity)
GO:0015187 (glycine transmembrane transporter activity)
GO:0015293 (symporter activity)
GO:0015375 (glycine:sodium symporter activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006836 (neurotransmitter transport)
GO:0007268 (chemical synaptic transmission)
GO:0015816 (glycine transport)
GO:0060012 (synaptic transmission, glycinergic)
GO:1903804 (glycine import across plasma membrane)
Wikipedia Glycine_transporter_2

Target Cross References - Protein

CGD Hyperekplexia 3
Human Protein Atlas ENSG00000165970
Guide to Pharmacology 936
Open Targets ENSG00000165970
PharmGKB PA35911
Reactome R-HSA-442660 (Na+/Cl- dependent neurotransmitter transporters.)
R-HSA-5619089 (Defective SLC6A5 causes hyperekplexia 3 (HKPX3).)
UniProt O95288 Q4VAM7 Q9BX77 Q9Y345

Target Cross References - Domain

InterPro IPR000175 (Na/ntran_symport.)
IPR037272 (SNS_sf.)
Pfam PF00209 (SNF)