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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3058
Preferred Name Sodium/hydrogen exchanger 5
Synonyms NHE-5 | NHE5 | Na(+)/H(+) exchanger 5 | SLC9A5 | Sodium/hydrogen exchanger 5 | Solute carrier family 9 member 5
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc09 family of sodium/hydrogen exchangers

Target Components

Component Description Relationship Accession
Sodium/hydrogen exchanger 5 SINGLE PROTEIN Q14940

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000135740
Ensembl ENSG00000135740
GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0015297 (antiporter activity)
GO:0015299 (solute:proton antiporter activity)
GO:0015385 (sodium:proton antiporter activity)
GO:0015386 (potassium:proton antiporter activity)
GO Biological Process GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006812 (cation transport)
GO:0006814 (sodium ion transport)
GO:0006885 (regulation of pH)
GO:0051453 (regulation of intracellular pH)
GO:0055085 (transmembrane transport)
GO:0071805 (potassium ion transmembrane transport)
GO:0098719 (sodium ion import across plasma membrane)
GO:1902600 (hydrogen ion transmembrane transport)
Wikipedia SLC9A5

Target Cross References - Protein

canSAR Q14940
Human Protein Atlas ENSG00000135740
IntAct Q14940
Guide to Pharmacology 952
Open Targets ENSG00000135740
PharmGKB PA35934
Reactome R-HSA-425986 (Sodium/Proton exchangers.)
UniProt A5PKY7 Q14940 Q9Y626

Target Cross References - Domain

InterPro IPR004709 (NaH_exchanger.)
IPR006153 (Cation/H_exchanger.)
IPR018410 (Na/H_exchanger_3/5.)
IPR018422 (Cation/H_exchanger_CPA1.)
Pfam PF00999 (Na_H_Exchanger)