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Target Report Card

Target Name and Classification

Target ID CHEMBL3055
Preferred Name Cyclin-dependent kinase 7
Synonyms 39 kDa protein kinase | CAK | CAK1 | CDK-activating kinase 1 | CDK7 | CDKN7 | Cell division protein kinase 7 | Cyclin-dependent kinase 7 | MO15 | STK1 | Serine/threonine-protein kinase 1 | TFIIH basal transcription factor complex kinase subunit | p39 Mo15
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase cdk family > cmgc protein kinase cdk7 subfamily

Target Components

Component Description Relationship Accession
Cyclin-dependent kinase 7 SINGLE PROTEIN P50613

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3559691 Cyclin-dependent kinase PROTEIN FAMILY
CHEMBL2111288 Cyclin-dependent kinase 7/ cyclin H PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL428690 ALVOCIDIB Cyclin-dependent kinase 7 inhibitor 3 PubMed PubMed
CHEMBL14762 SELICICLIB Cyclin-dependent kinase 7 inhibitor 2 PubMed PubMed PubMed
CHEMBL296468 BMS-387032 Cyclin-dependent kinase 7 inhibitor 1 PubMed PubMed
CHEMBL1944698 TG-02 Cyclin-dependent kinase 7 inhibitor 1 PubMed
CHEMBL3545083 RGB-286638 Cyclin-dependent kinase 7 inhibitor 1 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000134058 ENSG00000277273
Ensembl ENSG00000134058 ENSG00000277273
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005675 (holo TFIIH complex)
GO:0005737 (cytoplasm)
GO:0019907 (cyclin-dependent protein kinase activating kinase holoenzyme complex)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070985 (TFIIK complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003713 (transcription coactivator activity)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004693 (cyclin-dependent protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008022 (protein C-terminus binding)
GO:0008094 (DNA-dependent ATPase activity)
GO:0008353 (RNA polymerase II carboxy-terminal domain kinase activity)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0050681 (androgen receptor binding)
GO Biological Process GO:0000079 (regulation of cyclin-dependent protein serine/threonine kinase activity)
GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0000086 (G2/M transition of mitotic cell cycle)
GO:0006281 (DNA repair)
GO:0006283 (transcription-coupled nucleotide-excision repair)
GO:0006294 (nucleotide-excision repair, preincision complex assembly)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006361 (transcription initiation from RNA polymerase I promoter)
GO:0006362 (transcription elongation from RNA polymerase I promoter)
GO:0006363 (termination of RNA polymerase I transcription)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0006368 (transcription elongation from RNA polymerase II promoter)
GO:0006370 (7-methylguanosine mRNA capping)
GO:0006468 (protein phosphorylation)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0007049 (cell cycle)
GO:0007050 (cell cycle arrest)
GO:0008283 (cell proliferation)
GO:0016310 (phosphorylation)
GO:0030521 (androgen receptor signaling pathway)
GO:0042795 (snRNA transcription from RNA polymerase II promoter)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0050821 (protein stabilization)
GO:0051301 (cell division)
Wikipedia Cyclin-dependent_kinase_7

Target Cross References - Protein

canSAR P50613
Human Protein Atlas ENSG00000134058 ENSG00000277273
IntAct P50613
Guide to Pharmacology 1979
Open Targets ENSG00000134058 ENSG00000277273
PharmGKB PA26314
Pharos P50613 (Tchem)
Reactome R-HSA-112382 (Formation of RNA Pol II elongation complex.)
R-HSA-113418 (Formation of the Early Elongation Complex.)
R-HSA-167152 (Formation of HIV elongation complex in the absence of HIV Tat.)
R-HSA-167158 (Formation of the HIV-1 Early Elongation Complex.)
R-HSA-167160 (RNA Pol II CTD phosphorylation and interaction with CE during HIV infection.)
R-HSA-167161 (HIV Transcription Initiation.)
R-HSA-167162 (RNA Polymerase II HIV Promoter Escape.)
R-HSA-167172 (Transcription of the HIV genome.)
R-HSA-167200 (Formation of HIV-1 elongation complex containing HIV-1 Tat.)
R-HSA-167246 (Tat-mediated elongation of the HIV-1 transcript.)
R-HSA-427413 (NoRC negatively regulates rRNA expression.)
R-HSA-5696395 (Formation of Incision Complex in GG-NER.)
R-HSA-674695 (RNA Polymerase II Pre-transcription Events.)
R-HSA-6781823 (Formation of TC-NER Pre-Incision Complex.)
R-HSA-6781827 (Transcription-Coupled Nucleotide Excision Repair (TC-NER).)
R-HSA-6782135 (Dual incision in TC-NER.)
R-HSA-6782210 (Gap-filling DNA repair synthesis and ligation in TC-NER.)
R-HSA-6796648 (TP53 Regulates Transcription of DNA Repair Genes.)
R-HSA-6807505 (RNA polymerase II transcribes snRNA genes.)
R-HSA-69202 (Cyclin E associated events during G1/S transition.)
R-HSA-69231 (Cyclin D associated events in G1.)
R-HSA-69273 (Cyclin A/B1/B2 associated events during G2/M transition.)
R-HSA-69656 (Cyclin A:Cdk2-associated events at S phase entry.)
R-HSA-72086 (mRNA Capping.)
R-HSA-73762 (RNA Polymerase I Transcription Initiation.)
R-HSA-73772 (RNA Polymerase I Promoter Escape.)
R-HSA-73776 (RNA Polymerase II Promoter Escape.)
R-HSA-73777 (RNA Polymerase I Chain Elongation.)
R-HSA-73779 (RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.)
R-HSA-73863 (RNA Polymerase I Transcription Termination.)
R-HSA-75953 (RNA Polymerase II Transcription Initiation.)
R-HSA-75955 (RNA Polymerase II Transcription Elongation.)
R-HSA-76042 (RNA Polymerase II Transcription Initiation And Promoter Clearance.)
R-HSA-77075 (RNA Pol II CTD phosphorylation and interaction with CE.)
R-HSA-8939236 (RUNX1 regulates transcription of genes involved in differentiation of HSCs.)
UniProt P50613 Q9BS60 Q9UE19

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR037770 (CDK7.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure