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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3055
Target Type SINGLE PROTEIN
Preferred Name Cyclin-dependent kinase 7
Synonyms 39 kDa protein kinase | CAK | CAK1 | CDK-activating kinase 1 | CDK7 | CDKN7 | Cell division protein kinase 7 | Cyclin-dependent kinase 7 | MO15 | STK1 | Serine/threonine-protein kinase 1 | TFIIH basal transcription factor complex kinase subunit | p39 Mo15
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase cdk family > cmgc protein kinase cdk7 subfamily

Target Components

Component Description Relationship Accession
Cyclin-dependent kinase 7 SINGLE PROTEIN P50613

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111288 Cyclin-dependent kinase 7/ cyclin H PROTEIN COMPLEX
CHEMBL3038473 CDK7/Cyclin H/MNAT1 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000134058
Ensembl ENSG00000134058
GO Cellular Component GO:0005675 (holo TFIIH complex)
GO:0005739 (mitochondrion)
GO Molecular Function GO:0003713 (transcription coactivator activity)
GO:0004693 (cyclin-dependent protein kinase activity)
GO:0005524 (ATP binding)
GO:0008022 (protein C-terminus binding)
GO:0008094 (DNA-dependent ATPase activity)
GO:0008353 (RNA polymerase II carboxy-terminal domain kinase activity)
GO:0050681 (androgen receptor binding)
GO Biological Process GO:0000079 (regulation of cyclin-dependent protein kinase activity)
GO:0000080 (G1 phase of mitotic cell cycle)
GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0000084 (S phase of mitotic cell cycle)
GO:0000086 (G2/M transition of mitotic cell cycle)
GO:0000718 (nucleotide-excision repair, DNA damage removal)
GO:0006283 (transcription-coupled nucleotide-excision repair)
GO:0006361 (transcription initiation from RNA polymerase I promoter)
GO:0006362 (transcription elongation from RNA polymerase I promoter)
GO:0006363 (termination of RNA polymerase I transcription)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0006368 (transcription elongation from RNA polymerase II promoter)
GO:0006370 (mRNA capping)
GO:0006468 (protein phosphorylation)
GO:0008283 (cell proliferation)
GO:0016032 (viral reproduction)
GO:0030521 (androgen receptor signaling pathway)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0050434 (positive regulation of viral transcription)
GO:0051301 (cell division)
Wikipedia Cyclin-dependent_kinase_7

Target Cross References - Protein

canSAR P50613
Human Protein Atlas ENSG00000134058
IntAct P50613
Guide to Pharmacology 1979 (cyclin-dependent kinase 7)
PharmGKB PA26314
Reactome REACT_152 (Cell Cycle, Mitotic.)
REACT_1675 (mRNA Processing.)
REACT_1788 (Transcription.)
REACT_216 (DNA Repair.)
REACT_6185 (HIV Infection.)
REACT_71 (Gene Expression.)
UniProt P50613 Q9BS60 Q9UE19

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR002290 (Ser/Thr_prot_kinase_dom.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 1UA2
CREDO 1UA2
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