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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3055
Preferred Name Cyclin-dependent kinase 7
Synonyms 39 kDa protein kinase | CAK | CAK1 | CDK-activating kinase 1 | CDK7 | CDKN7 | Cell division protein kinase 7 | Cyclin-dependent kinase 7 | MO15 | STK1 | Serine/threonine-protein kinase 1 | TFIIH basal transcription factor complex kinase subunit | p39 Mo15
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase cdk family > cmgc protein kinase cdk7 subfamily

Target Components

Component Description Relationship Accession
Cyclin-dependent kinase 7 SINGLE PROTEIN P50613

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111288 Cyclin-dependent kinase 7/ cyclin H PROTEIN COMPLEX
CHEMBL3559691 Cyclin-dependent kinase PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL428690 ALVOCIDIB Cyclin-dependent kinase 7 inhibitor 3
CHEMBL14762 SELICICLIB Cyclin-dependent kinase 7 inhibitor 2
CHEMBL296468 BMS-387032 Cyclin-dependent kinase 7 inhibitor 1
CHEMBL1944698 TG-02 Cyclin-dependent kinase 7 inhibitor 1
CHEMBL3545083 RGB-286638 Cyclin-dependent kinase 7 inhibitor 1

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000134058
Ensembl ENSG00000134058
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005675 (holo TFIIH complex)
GO:0005739 (mitochondrion)
GO:0005634 (nucleus)
GO:0048471 (perinuclear region of cytoplasm)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0008353 (RNA polymerase II carboxy-terminal domain kinase activity)
GO:0004693 (cyclin-dependent protein serine/threonine kinase activity)
GO:0005524 (ATP binding)
GO:0003713 (transcription coactivator activity)
GO:0008094 (DNA-dependent ATPase activity)
GO:0050681 (androgen receptor binding)
GO:0004672 (protein kinase activity)
GO:0008022 (protein C-terminus binding)
GO Biological Process GO:0006283 (transcription-coupled nucleotide-excision repair)
GO:0040029 (regulation of gene expression, epigenetic)
GO:0006281 (DNA repair)
GO:0006361 (transcription initiation from RNA polymerase I promoter)
GO:0016032 (viral process)
GO:0030521 (androgen receptor signaling pathway)
GO:0045814 (negative regulation of gene expression, epigenetic)
GO:0006360 (transcription from RNA polymerase I promoter)
GO:0010467 (gene expression)
GO:0000278 (mitotic cell cycle)
GO:0070911 (global genome nucleotide-excision repair)
GO:0000079 (regulation of cyclin-dependent protein serine/threonine kinase activity)
GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0000086 (G2/M transition of mitotic cell cycle)
GO:0006289 (nucleotide-excision repair)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006368 (transcription elongation from RNA polymerase II promoter)
GO:0006370 (7-methylguanosine mRNA capping)
GO:0008283 (cell proliferation)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0051301 (cell division)
GO:0006362 (transcription elongation from RNA polymerase I promoter)
GO:0006363 (termination of RNA polymerase I transcription)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0007050 (cell cycle arrest)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0050434 (positive regulation of viral transcription)
Wikipedia Cyclin-dependent_kinase_7

Target Cross References - Protein

canSAR P50613
Human Protein Atlas ENSG00000134058
IntAct P50613
Guide to Pharmacology 1979 (cyclin-dependent kinase 7)
PharmGKB PA26314
UniProt Q9UE19 Q9BS60 P50613

Target Cross References - Domain

InterPro IPR008271 (Ser/Thr_kinase_AS.)
IPR000719 (Prot_kinase_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR002290 (Ser/Thr_dual-sp_kinase.)
IPR011009 (Kinase-like_dom.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure