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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3045
Target Type SINGLE PROTEIN
Preferred Name Protein kinase C beta
Synonyms PKC-B | PKC-beta | PKCB | PRKCB | PRKCB1 | Protein kinase C beta type
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase pkc family > agc protein kinase pkc alpha subfamily

Target Components

Component Description Relationship Accession
Protein kinase C beta type SINGLE PROTEIN P05771

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3137267 PKC alpha and beta-2 PROTEIN FAMILY
CHEMBL2093867 Protein kinase C (PKC) PROTEIN FAMILY
CHEMBL2096620 Protein kinase C, PKC; classical/novel PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL300138 ENZASTAURIN Protein kinase C beta inhibitor 3 PubMed PubMed
CHEMBL91829 RUBOXISTAURIN Protein kinase C beta inhibitor 3 Other PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000166501
Ensembl ENSG00000166501
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003682 (chromatin binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004697 (protein kinase C activity)
GO:0004698 (calcium-dependent protein kinase C activity)
GO:0005080 (protein kinase C binding)
GO:0005246 (calcium channel regulator activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008270 (zinc ion binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0030374 (ligand-dependent nuclear receptor transcription coactivator activity)
GO:0035403 (histone kinase activity (H3-T6 specific))
GO:0042393 (histone binding)
GO:0046872 (metal ion binding)
GO:0050681 (androgen receptor binding)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0002250 (adaptive immune response)
GO:0002376 (immune system process)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006468 (protein phosphorylation)
GO:0006816 (calcium ion transport)
GO:0006874 (cellular calcium ion homeostasis)
GO:0006915 (apoptotic process)
GO:0007077 (mitotic nuclear envelope disassembly)
GO:0007165 (signal transduction)
GO:0010829 (negative regulation of glucose transport)
GO:0016310 (phosphorylation)
GO:0016568 (chromatin modification)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0030168 (platelet activation)
GO:0030949 (positive regulation of vascular endothelial growth factor receptor signaling pathway)
GO:0035408 (histone H3-T6 phosphorylation)
GO:0035556 (intracellular signal transduction)
GO:0042113 (B cell activation)
GO:0042953 (lipoprotein transport)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0045766 (positive regulation of angiogenesis)
GO:0046627 (negative regulation of insulin receptor signaling pathway)
GO:0050853 (B cell receptor signaling pathway)
GO:0050861 (positive regulation of B cell receptor signaling pathway)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0071322 (cellular response to carbohydrate stimulus)
Wikipedia PRKCB1

Target Cross References - Protein

canSAR P05771
Human Protein Atlas ENSG00000166501
IntAct P05771
Guide to Pharmacology 1483
Open Targets ENSG00000166501
PharmGKB PA33761
Pharos P05771 (Tclin)
Reactome R-HSA-114516 (Disinhibition of SNARE formation.)
R-HSA-1169091 (Activation of NF-kappaB in B cells.)
R-HSA-416993 (Trafficking of GluR2-containing AMPA receptors.)
R-HSA-418597 (G alpha (z) signalling events.)
R-HSA-4419969 (Depolymerisation of the Nuclear Lamina.)
R-HSA-5099900 (WNT5A-dependent internalization of FZD4.)
R-HSA-5218921 (VEGFR2 mediated cell proliferation.)
R-HSA-76005 (Response to elevated platelet cytosolic Ca2+.)
UniProt C5IFJ8 D3DWF5 O43744 P05127 P05771 Q15138 Q93060 Q9UE49 Q9UE50 Q9UEH8 Q9UJ30 Q9UJ33

Target Cross References - Domain

InterPro IPR000008 (C2_dom.)
IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR002219 (PE/DAG-bd.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR014375 (Protein_kinase_C_a/b/g.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017892 (Pkinase_C.)
IPR020454 (DAG/PE-bd.)
Pfam PF00069 (Pkinase)
PF00130 (C1_1)
PF00168 (C2)
PF00433 (Pkinase_C)

Target Cross References - Structure

PDBe 2I0E
CREDO 2I0E
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