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Target Report Card

Target Name and Classification

Target ID CHEMBL3040
Preferred Name CDC45-related protein
Synonyms CDC45 | CDC45L | CDC45L2 | Cell division control protein 45 homolog | PORC-PI-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other cytosolic protein
  • other nuclear protein

Target Components

Component Description Relationship Accession
Cell division control protein 45 homolog SINGLE PROTEIN O75419

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000093009
Ensembl ENSG00000093009
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005656 (nuclear pre-replicative complex)
GO:0005737 (cytoplasm)
GO:0005813 (centrosome)
GO:0031261 (DNA replication preinitiation complex)
GO:0031298 (replication fork protection complex)
GO Molecular Function GO:0003682 (chromatin binding)
GO:0003688 (DNA replication origin binding)
GO:0003697 (single-stranded DNA binding)
GO:0005515 (protein binding)
GO:0043138 (3'-5' DNA helicase activity)
GO Biological Process GO:0000076 (DNA replication checkpoint)
GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0000083 (regulation of transcription involved in G1/S transition of mitotic cell cycle)
GO:0000727 (double-strand break repair via break-induced replication)
GO:0006260 (DNA replication)
GO:0006267 (pre-replicative complex assembly involved in nuclear cell cycle DNA replication)
GO:0006270 (DNA replication initiation)
GO:0007049 (cell cycle)
GO:0031938 (regulation of chromatin silencing at telomere)
GO:0032508 (DNA duplex unwinding)
GO:1900087 (positive regulation of G1/S transition of mitotic cell cycle)
GO:1902977 (mitotic DNA replication preinitiation complex assembly)
Wikipedia CDC45-related_protein

Target Cross References - Protein

canSAR O75419
Human Protein Atlas ENSG00000093009
IntAct O75419
Open Targets ENSG00000093009
PharmGKB PA371
Reactome R-HSA-113510 (E2F mediated regulation of DNA replication.)
R-HSA-176187 (Activation of ATR in response to replication stress.)
R-HSA-176974 (Unwinding of DNA.)
R-HSA-68962 (Activation of the pre-replicative complex.)
R-HSA-69205 (G1/S-Specific Transcription.)
UniProt B4DDB4 B4DDU3 E9PDH7 O60856 O75419 Q20WK8 Q6UW54 Q9UP68

Target Cross References - Domain

InterPro IPR003874 (CDC45.)
Pfam PF02724 (CDC45)

Target Cross References - Structure