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Target Report Card

Target Name and Classification

Target ID CHEMBL3032
Target Type SINGLE PROTEIN
Preferred Name Protein kinase N2
Synonyms PKN gamma | PKN2 | PRK2 | PRKCL2 | Protein kinase C-like 2 | Protein-kinase C-related kinase 2 | Serine/threonine-protein kinase N2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase pkn family

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase N2 SINGLE PROTEIN Q16513

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000065243
Ensembl ENSG00000065243
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005813 (centrosome)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005886 (plasma membrane)
GO:0005913 (cell-cell adherens junction)
GO:0016020 (membrane)
GO:0030027 (lamellipodium)
GO:0030054 (cell junction)
GO:0030496 (midbody)
GO:0032154 (cleavage furrow)
GO:0042995 (cell projection)
GO:0043234 (protein complex)
GO:0043296 (apical junction complex)
GO:0045111 (intermediate filament cytoskeleton)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004697 (protein kinase C activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0042826 (histone deacetylase binding)
GO:0044822 (poly(A) RNA binding)
GO:0070063 (RNA polymerase binding)
GO:0098641 (cadherin binding involved in cell-cell adhesion)
GO Biological Process GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007049 (cell cycle)
GO:0007155 (cell adhesion)
GO:0007165 (signal transduction)
GO:0010631 (epithelial cell migration)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0032467 (positive regulation of cytokinesis)
GO:0035556 (intracellular signal transduction)
GO:0043297 (apical junction assembly)
GO:0045070 (positive regulation of viral genome replication)
GO:0045931 (positive regulation of mitotic cell cycle)
GO:0051301 (cell division)
GO:0098609 (cell-cell adhesion)
GO:2000145 (regulation of cell motility)
Wikipedia PKN2

Target Cross References - Protein

canSAR Q16513
Human Protein Atlas ENSG00000065243
IntAct Q16513
Guide to Pharmacology 1521
Open Targets ENSG00000065243
PharmGKB PA33770
Pharos Q16513 (Tchem)
Reactome R-HSA-5625740 (RHO GTPases activate PKNs.)
UniProt B4DQ21 B4DTP5 B4DVG1 D3DT24 Q08AF4 Q16513 Q9H1W4

Target Cross References - Domain

InterPro IPR000008 (C2_dom.)
IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR011072 (HR1_rho-bd.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017892 (Pkinase_C.)
Pfam PF00069 (Pkinase)
PF00433 (Pkinase_C)
PF02185 (HR1)

Target Cross References - Structure

PDBe 4CRS 4RRV
CREDO 4CRS 4RRV
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