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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3019
Preferred Name Cytochrome P450 3A5
Synonyms CYP3A5 | CYPIIIA5 | Cytochrome P450 3A5 | Cytochrome P450 HLp2 | Cytochrome P450-PCN3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 3 > cytochrome p450 family 3a > cytochrome p450 3a5

Target Components

Component Description Relationship Accession
Cytochrome P450 3A5 SINGLE PROTEIN P20815

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111472 Cytochrome P450 3A4/3A5 PROTEIN FAMILY
CHEMBL2364675 Cytochrome P450 3A PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000106258
Ensembl ENSG00000106258
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0031090 (organelle membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0016491 (oxidoreductase activity)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0016712 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)
GO:0019825 (oxygen binding)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO:0070330 (aromatase activity)
GO:0101020 (estrogen 16-alpha-hydroxylase activity)
GO Biological Process GO:0002933 (lipid hydroxylation)
GO:0006805 (xenobiotic metabolic process)
GO:0008202 (steroid metabolic process)
GO:0009822 (alkaloid catabolic process)
GO:0042737 (drug catabolic process)
GO:0055114 (oxidation-reduction process)
GO:0070989 (oxidative demethylation)
Wikipedia CYP3A5

Target Cross References - Protein

canSAR P20815
CGD Drug metabolism, CYP3A5-related
Human Protein Atlas ENSG00000106258
IntAct P20815
Guide to Pharmacology 1338
Open Targets ENSG00000106258
PharmGKB PA131
Reactome R-HSA-211981 (Xenobiotics.)
R-HSA-5423646 (Aflatoxin activation and detoxification.)
UniProt A4D289 B7Z5I7 P20815 Q53WY8 Q75MV0 Q9HB56

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002402 (Cyt_P450_E_grp-II.)
IPR008072 (Cyt_P450_E_CYP3A.)
IPR017972 (Cyt_P450_CS.)
IPR036396 (Cyt_P450_sf.)
Pfam PF00067 (p450)

Target Cross References - Structure