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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL301
Target Type SINGLE PROTEIN
Preferred Name Cyclin-dependent kinase 2
Synonyms CDK2 | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 | p33 protein kinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase cdk family > cmgc protein kinase cdc2 subfamily

Target Components

Component Description Relationship Accession
Cyclin-dependent kinase 2 SINGLE PROTEIN P24941

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3559691 Cyclin-dependent kinase PROTEIN FAMILY
CHEMBL2094126 Cyclin-dependent kinase 2/cyclin E PROTEIN COMPLEX
CHEMBL3038469 CDK2/Cyclin A PROTEIN COMPLEX
CHEMBL2094128 Cyclin-dependent kinase 2/cyclin A PROTEIN COMPLEX
CHEMBL3038517 CDK2/CDK4 PROTEIN FAMILY
CHEMBL3038470 CDK2/Cyclin A1 PROTEIN COMPLEX
CHEMBL1907605 Cyclin-dependent kinase 2/cyclin E1 PROTEIN COMPLEX
CHEMBL2111326 Cyclin-dependent kinase 2 and 4 (CDK2 and CDK4) SELECTIVITY GROUP

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL428690 ALVOCIDIB Cyclin-dependent kinase 2 inhibitor 3 PubMed PubMed
CHEMBL2103840 DINACICLIB Cyclin-dependent kinase 2 inhibitor 3 PubMed
CHEMBL14762 SELICICLIB Cyclin-dependent kinase 2 inhibitor 2 PubMed PubMed PubMed
CHEMBL384304 RG-547 Cyclin-dependent kinase 2 inhibitor 2
CHEMBL564829 MILCICLIB Cyclin-dependent kinase 2 inhibitor 2 PubMed PubMed
CHEMBL574737 (7S)-HYDROXYL-STAUROSPORINE Cyclin-dependent kinase 2 inhibitor 2 Other PubMed PubMed
CHEMBL296468 BMS-387032 Cyclin-dependent kinase 2 inhibitor 1 PubMed PubMed
CHEMBL258805 INDIRUBIN SULFATE Cyclin-dependent kinase 2 inhibitor 1 PubMed
CHEMBL1944698 TG-02 Cyclin-dependent kinase 2 inhibitor 1 PubMed
CHEMBL3545083 RGB-286638 Cyclin-dependent kinase 2 inhibitor 1 PubMed
CHEMBL3545420 AG-24322 Cyclin-dependent kinase 2 inhibitor 1 Other PubMed
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Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000123374
Ensembl ENSG00000123374
GO Cellular Component GO:0000307 (cyclin-dependent protein kinase holoenzyme complex)
GO:0000781 (chromosome, telomeric region)
GO:0000793 (condensed chromosome)
GO:0000805 (X chromosome)
GO:0000806 (Y chromosome)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005667 (transcription factor complex)
GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005813 (centrosome)
GO:0005815 (microtubule organizing center)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0015030 (Cajal body)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004693 (cyclin-dependent protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0030332 (cyclin binding)
GO:0032403 (protein complex binding)
GO:0035173 (histone kinase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0000086 (G2/M transition of mitotic cell cycle)
GO:0002088 (lens development in camera-type eye)
GO:0006260 (DNA replication)
GO:0006281 (DNA repair)
GO:0006468 (protein phosphorylation)
GO:0006813 (potassium ion transport)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0006977 (DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)
GO:0007049 (cell cycle)
GO:0007067 (mitotic nuclear division)
GO:0007099 (centriole replication)
GO:0007126 (meiotic nuclear division)
GO:0007265 (Ras protein signal transduction)
GO:0008284 (positive regulation of cell proliferation)
GO:0009636 (response to toxic substance)
GO:0016310 (phosphorylation)
GO:0016572 (histone phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0031100 (organ regeneration)
GO:0031571 (mitotic G1 DNA damage checkpoint)
GO:0032298 (positive regulation of DNA-dependent DNA replication initiation)
GO:0032355 (response to estradiol)
GO:0032869 (cellular response to insulin stimulus)
GO:0042493 (response to drug)
GO:0045471 (response to ethanol)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0046686 (response to cadmium ion)
GO:0051298 (centrosome duplication)
GO:0051301 (cell division)
GO:0051321 (meiotic cell cycle)
GO:0051436 (negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle)
GO:0051439 (regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle)
GO:0051591 (response to cAMP)
GO:0051602 (response to electrical stimulus)
GO:0051726 (regulation of cell cycle)
GO:0060968 (regulation of gene silencing)
GO:0071732 (cellular response to nitric oxide)
GO:1901796 (regulation of signal transduction by p53 class mediator)
Wikipedia Cyclin-dependent_kinase_2

Target Cross References - Protein

canSAR P24941
Human Protein Atlas ENSG00000123374
IntAct P24941
Guide to Pharmacology 1973
Open Targets ENSG00000123374
PharmGKB PA101
Pharos P24941 (Tchem)
Reactome R-HSA-1538133 (G0 and Early G1.)
R-HSA-176187 (Activation of ATR in response to replication stress.)
R-HSA-176408 (Regulation of APC/C activators between G1/S and early anaphase.)
R-HSA-187577 (SCF(Skp2)-mediated degradation of p27/p21.)
R-HSA-2559582 (Senescence-Associated Secretory Phenotype (SASP).)
R-HSA-2559586 (DNA Damage/Telomere Stress Induced Senescence.)
R-HSA-5693607 (Processing of DNA double-strand break ends.)
R-HSA-6804116 (TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest.)
R-HSA-6804756 (Regulation of TP53 Activity through Phosphorylation.)
R-HSA-6804757 (Regulation of TP53 Degradation.)
R-HSA-68911 (G2 Phase.)
R-HSA-68949 (Orc1 removal from chromatin.)
R-HSA-68962 (Activation of the pre-replicative complex.)
R-HSA-69017 (CDK-mediated phosphorylation and removal of Cdc6.)
R-HSA-69200 (Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes.)
R-HSA-69202 (Cyclin E associated events during G1/S transition.)
R-HSA-69273 (Cyclin A/B1 associated events during G2/M transition.)
R-HSA-69563 (p53-Dependent G1 DNA Damage Response.)
R-HSA-69656 (Cyclin A:Cdk2-associated events at S phase entry.)
R-HSA-8849470 (PTK6 Regulates Cell Cycle.)
R-HSA-912446 (Meiotic recombination.)
R-HSA-983231 (Factors involved in megakaryocyte development and platelet production.)
UniProt A8K7C6 O75100 P24941

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 1AQ1 1B38 1B39 1BUH 1CKP 1DI8 1DM2 1E1V 1E1X 1E9H 1F5Q 1FIN 1FQ1 1FVT 1FVV 1G5S 1GIH 1GII 1GIJ 1GY3 1GZ8 1H00 1H01 1H07
1H08 1H0V 1H0W 1H1P 1H1Q 1H1R 1H1S 1H24 1H25 1H26 1H27 1H28 1HCK 1HCL 1JST 1JSU 1JSV 1JVP 1KE5 1KE6 1KE7 1KE8 1KE9 1OGU 1OI9 1OIQ 1OIR 1OIT 1OIU 1OIY 1OKV 1OKW 1OL1 1OL2 1P2A 1P5E 1PF8 1PKD 1PW2 1PXI 1PXJ 1PXK 1PXL 1PXM 1PXN 1PXO 1PXP 1PYE 1QMZ 1R78 1URC 1URW 1V1K 1VYW 1VYZ 1W0X 1W8C 1W98 1WCC 1Y8Y 1Y91 1YKR 2A0C 2A4L 2B52 2B53 2B54 2B55 2BHE 2BHH 2BKZ 2BPM 2BTR 2BTS 2C4G 2C5N 2C5O 2C5V 2C5X 2C5Y 2C68 2C69 2C6I 2C6K 2C6L 2C6M 2C6O 2C6T 2CCH 2CCI 2CJM 2CLX 2DS1 2DUV 2EXM 2FVD 2G9X 2I40 2IW6 2IW8 2IW9 2J9M 2JGZ 2R3F 2R3G 2R3H 2R3I 2R3J 2R3K 2R3L 2R3M 2R3N 2R3O 2R3P 2R3Q 2R3R 2R64 2UUE 2UZB 2UZD 2UZE 2UZL 2UZN 2UZO 2V0D 2V22 2VTA 2VTH 2VTI 2VTJ 2VTL 2VTM 2VTN 2VTO 2VTP 2VTQ 2VTR 2VTS 2VTT 2VU3 2VV9 2W05 2W06 2W17 2W1H 2WEV 2WFY 2WHB 2WIH 2WIP 2WMA 2WMB 2WPA 2WXV 2X1N 2XMY 2XNB 3BHT 3BHU 3BHV 3DDP 3DDQ 3DOG 3EID 3EJ1 3EOC 3EZR 3EZV 3F5X 3FZ1 3IG7 3IGG 3LE6 3LFN 3LFQ 3LFS 3MY5 3NS9 3PJ8 3PXF 3PXQ 3PXR 3PXY 3PXZ 3PY0 3PY1 3QHR 3QHW 3QL8 3QQF 3QQG 3QQH 3QQJ 3QQK 3QQL 3QRT 3QRU 3QTQ 3QTR 3QTS 3QTU 3QTW 3QTX 3QTZ 3QU0 3QWJ 3QWK 3QX2 3QX4 3QXO 3QXP 3QZF 3QZG 3QZH 3QZI 3R1Q 3R1S 3R1Y 3R28 3R6X 3R71 3R73 3R7E 3R7I 3R7U 3R7V 3R7Y 3R83 3R8L 3R8M 3R8P 3R8U 3R8V 3R8Z 3R9D 3R9H 3R9N 3R9O 3RAH 3RAI 3RAK 3RAL 3RJC 3RK5 3RK7 3RK9 3RKB 3RM6 3RM7 3RMF 3RNI 3ROY 3RPO 3RPR 3RPV 3RPY 3RZB 3S00 3S0O 3S1H 3S2P 3SQQ 3SW4 3SW7 3TI1 3TIY 3TIZ 3TNW 3ULI 3UNJ 3UNK 3WBL 4ACM 4BCK 4BCM 4BCN 4BCO 4BCP 4BCQ 4BGH 4BZD 4CFM 4CFN 4CFU 4CFV 4CFW 4CFX 4D1X 4D1Z 4EK3 4EK4 4EK5 4EK6 4EK8 4EOI 4EOJ 4EOK 4EOL 4EOM 4EON 4EOO 4EOP 4EOQ 4EOR 4EOS 4ERW 4EZ3 4EZ7 4FKG 4FKI 4FKJ 4FKL 4FKO 4FKP 4FKQ 4FKR 4FKS 4FKT 4FKU 4FKV 4FKW 4FX3 4GCJ 4I3Z 4II5 4KD1 4LYN 4NJ3 4RJ3 5A14 5AND 5ANE 5ANG 5ANI 5ANJ 5ANK 5ANO 5CYI 5D1J 5FP5 5FP6 5IEV 5IEX 5IEY 5IF1 5K4J 5L2W 5LMK 5LQE
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CREDO 1AQ1 1B38 1B39 1BUH 1CKP 1DI8 1DM2 1E1V 1E1X 1E9H 1F5Q 1FIN 1FQ1 1FVT 1FVV 1G5S 1GIH 1GII 1GIJ 1GY3 1GZ8 1H00 1H01 1H07
1H08 1H0V 1H0W 1H1P 1H1Q 1H1R 1H1S 1H24 1H25 1H26 1H27 1H28 1HCK 1HCL 1JST 1JSU 1JSV 1JVP 1KE5 1KE6 1KE7 1KE8 1KE9 1OGU 1OI9 1OIQ 1OIR 1OIT 1OIU 1OIY 1OKV 1OKW 1OL1 1OL2 1P2A 1P5E 1PF8 1PKD 1PW2 1PXI 1PXJ 1PXK 1PXL 1PXM 1PXN 1PXO 1PXP 1PYE 1QMZ 1R78 1URC 1URW 1V1K 1VYW 1VYZ 1W0X 1W8C 1W98 1WCC 1Y8Y 1Y91 1YKR 2A0C 2A4L 2B52 2B53 2B54 2B55 2BHE 2BHH 2BKZ 2BPM 2BTR 2BTS 2C4G 2C5N 2C5O 2C5V 2C5X 2C5Y 2C68 2C69 2C6I 2C6K 2C6L 2C6M 2C6O 2C6T 2CCH 2CCI 2CJM 2CLX 2DS1 2DUV 2EXM 2FVD 2G9X 2I40 2IW6 2IW8 2IW9 2J9M 2JGZ 2R3F 2R3G 2R3H 2R3I 2R3J 2R3K 2R3L 2R3M 2R3N 2R3O 2R3P 2R3Q 2R3R 2R64 2UUE 2UZB 2UZD 2UZE 2UZL 2UZN 2UZO 2V0D 2V22 2VTA 2VTH 2VTI 2VTJ 2VTL 2VTM 2VTN 2VTO 2VTP 2VTQ 2VTR 2VTS 2VTT 2VU3 2VV9 2W05 2W06 2W17 2W1H 2WEV 2WFY 2WHB 2WIH 2WIP 2WMA 2WMB 2WPA 2WXV 2X1N 2XMY 2XNB 3BHT 3BHU 3BHV 3DDP 3DDQ 3DOG 3EID 3EJ1 3EOC 3EZR 3EZV 3F5X 3FZ1 3IG7 3IGG 3LE6 3LFN 3LFQ 3LFS 3MY5 3NS9 3PJ8 3PXF 3PXQ 3PXR 3PXY 3PXZ 3PY0 3PY1 3QHR 3QHW 3QL8 3QQF 3QQG 3QQH 3QQJ 3QQK 3QQL 3QRT 3QRU 3QTQ 3QTR 3QTS 3QTU 3QTW 3QTX 3QTZ 3QU0 3QWJ 3QWK 3QX2 3QX4 3QXO 3QXP 3QZF 3QZG 3QZH 3QZI 3R1Q 3R1S 3R1Y 3R28 3R6X 3R71 3R73 3R7E 3R7I 3R7U 3R7V 3R7Y 3R83 3R8L 3R8M 3R8P 3R8U 3R8V 3R8Z 3R9D 3R9H 3R9N 3R9O 3RAH 3RAI 3RAK 3RAL 3RJC 3RK5 3RK7 3RK9 3RKB 3RM6 3RM7 3RMF 3RNI 3ROY 3RPO 3RPR 3RPV 3RPY 3RZB 3S00 3S0O 3S1H 3S2P 3SQQ 3SW4 3SW7 3TI1 3TIY 3TIZ 3TNW 3ULI 3UNJ 3UNK 3WBL 4ACM 4BCK 4BCM 4BCN 4BCO 4BCP 4BCQ 4BGH 4BZD 4CFM 4CFN 4CFU 4CFV 4CFW 4CFX 4D1X 4D1Z 4EK3 4EK4 4EK5 4EK6 4EK8 4EOI 4EOJ 4EOK 4EOL 4EOM 4EON 4EOO 4EOP 4EOQ 4EOR 4EOS 4ERW 4EZ3 4EZ7 4FKG 4FKI 4FKJ 4FKL 4FKO 4FKP 4FKQ 4FKR 4FKS 4FKT 4FKU 4FKV 4FKW 4FX3 4GCJ 4I3Z 4II5 4KD1 4LYN 4NJ3 4RJ3 5A14 5AND 5ANE 5ANG 5ANI 5ANJ 5ANK 5ANO 5CYI 5D1J 5FP5 5FP6 5IEV 5IEX 5IEY 5IF1 5K4J 5L2W 5LMK 5LQE
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